dextromethorphan/bupropion (Pending FDA Approval)

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Dosing & Uses

Major Depressive Disorders

Pending FDA approval for major depressive disorders (MDD)

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Pharmacology

Mechanism of Action

Dextromethorphan: Uncompetitive N-methyl-D-aspartate receptor (NMDA) receptor antagonist (glutamate receptor modulator) with multimodal activity; also is an agonist of sigma-1 receptor

Bupropion: Serves to increase bioavailability of dextromethorphan; also inhibits norepinephrine and dopamine reuptake

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.