desonide (Rx)

Brand and Other Names:Desonate, DesOwen, more...Tridesilon, Verdeso
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream/lotion/ointment

  • 0.05%

foam

  • 0.05%

gel

  • 0.05%

Dermatoses

Cream/ointment/lotion: Apply sparingly to affected area(s) q8-12hr; discontinue therapy if control achieved and reassess diagnosis if no improvement within 4 weeks

Gel or foam: Apply q12hr; discontinue use when control is achieved

Dosing Considerations

If no improvement seen within 4 weeks, reassessment of diagnosis may be necessary; treatment beyond 4 consecutive weeks not recommended; do not use with occlusive dressings; avoid contact with eyes or other mucous membranes

For topical use only; not for oral, ophthalmic, or intravaginal use

Dosage Forms & Strengths

cream/lotion/ointment

  • 0.05%

foam

  • 0.05%

gel

  • 0.05%

Dermatoses

<3 years: Safety and efficacy not established

≥3 years: Apply foam or gel sparingly to affected area(s) q8-12hr; discontinue therapy if control achieved

Dosing Considerations

If no improvement seen within 4 weeks, reassessment of diagnosis may be necessary; treatment beyond 4 consecutive weeks not recommended; do not use with occlusive dressings; avoid contact with eyes or other mucous membranes

For topical use only; not for oral, ophthalmic, or intravaginal use

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Adverse Effects

Frequency Not Defined

Skin atrophy

Striae

Hypertension

Headache

Irritability

Hyperglycemia

Itching

Scaly skin

Acneform lesions

Pigmentation changes

HPA suppression (with higher potency used >2 wk)

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Warnings

Contraindications

None

Cautions

Shown to reversibly suppress the HPA axis; children may exhibit greater susceptibility to corticosteroid-induced HPA axis suppression and Cushing syndrome due to larger skin surface area to body weight ratio

Cushing’s syndrome, hyperglycemia, and unmasking of latent diabetes mellitus can result from systemic absorption of topical corticosteroids

Use medium-to-very high potency topical corticosteroids for <2 wk to reduce local and systemic adverse effects; avoid use on face, folds, groin owing to increased absorption

Use low potency topical corticosteroids for chronic therapy

May cause local skin adverse reactions; if irritation develops, discontinue treatment and institute appropriate therapy; allergic contact dermatitis with corticosteroids is usually diagnosed by observing a failure to heal rather than noticing a clinical exacerbation; corroborate with appropriate diagnostic patch testing

If concomitant skin infections are present or develop, initiate appropriate antifungal, antibacterial, or antiviral agent; if favorable response does not occur promptly, discontinue desonide until infection controlled

Use of topical corticosteroids may increase risk of posterior subcapsular cataracts and glaucoma

Avoid contact with eyes; advise patients to report any visual symptoms and consider referral to ophthalmologist for evaluation

Because of potential for systemic absorption, use of topical corticosteroids may require that patients be periodically evaluated for HPA axis suppression; factors that predispose a patient using a topical corticosteroid to HPA axis suppression include use of more potent steroids, use over large surface areas, use over prolonged periods, use under occlusion, use on an altered skin barrier, and use in patients with liver failure

An ACTH stimulation test may be helpful in evaluating patients for HPA axis suppression; if HPA axis suppression documented, an attempt should be made to gradually withdraw drug, to reduce frequency of application, or to substitute a less potent steroid; manifestations of adrenal insufficiency may require supplemental systemic corticosteroids; recovery of HPA axis function is generally prompt and complete upon discontinuation of topical corticosteroids

Use of more than one corticosteroid-containing product at the same time may increase total systemic corticosteroid exposure

Local adverse reactions may be more likely to occur with occlusive use, prolonged use or use of higher potency corticosteroids; reactions may include skin atrophy, striae, telangiectasias, burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, and miliaria; some local adverse reactions may be irreversible

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Pregnancy & Lactation

Pregnancy

There are no available data on use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes

Animal data

  • In animal reproduction studies, topical administration (cream 0.05%) during organogenesis caused malformations characteristic of corticosteroids in rats and in rabbits; available data do not allow calculation of relevant comparisons of systemic exposure between animals and humans after topical use

Lactation

There are no data on presence in human or animal milk, effects on breastfed infant, or on milk production; unknown whether topical administration could result in sufficient systemic absorption to produce detectable quantities in human milk; developmental and health benefits should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from therapy or from the underlying maternal condition

To minimize potential exposure to breastfed infant via breast milk, use on smallest area of skin and for shortest duration possible while breastfeeding; advise breastfeeding women to wash off any amount that may have been applied to nipple and areola prior to breastfeeding to avoid direct infant exposure

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation

Pharmacokinetics

Absorption: Dependent on nature of skin at application; occlusion and inflammation may increase absorption

Metabolism: Liver

Excretion: Primarily urine

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Images

BRAND FORM. UNIT PRICE PILL IMAGE
desonide topical
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0.05 % cream
desonide topical
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0.05 % ointment
desonide topical
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0.05 % ointment
desonide topical
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0.05 % cream
desonide topical
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0.05 % lotion
desonide topical
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0.05 % ointment
desonide topical
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0.05 % lotion
desonide topical
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0.05 % cream
desonide topical
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0.05 % lotion
desonide topical
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0.05 % ointment
desonide topical
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0.05 % ointment
desonide topical
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0.05 % ointment
desonide topical
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0.05 % ointment
desonide topical
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0.05 % ointment
desonide topical
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0.05 % lotion
desonide topical
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0.05 % ointment
desonide topical
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0.05 % lotion
desonide topical
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0.05 % lotion
desonide topical
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0.05 % ointment
desonide topical
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0.05 % ointment
desonide topical
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0.05 % cream
desonide topical
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0.05 % cream
desonide topical
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0.05 % cream
desonide topical
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0.05 % lotion
desonide topical
-
0.05 % ointment
desonide topical
-
0.05 % ointment
desonide topical
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0.05 % lotion
desonide topical
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0.05 % cream
desonide topical
-
0.05 % ointment
desonide topical
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0.05 % cream
desonide topical
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0.05 % ointment
desonide topical
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0.05 % ointment
desonide topical
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0.05 % cream
desonide topical
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0.05 % cream
desonide topical
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0.05 % lotion
desonide topical
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0.05 % cream
desonide topical
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0.05 % cream
desonide topical
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0.05 % lotion
desonide topical
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0.05 % lotion
desonide topical
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0.05 % cream
desonide topical
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0.05 % cream
desonide topical
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0.05 % lotion
Desonate topical
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0.05 % gel
Verdeso topical
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0.05 % foam
DesOwen topical
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0.05 % cream
DesOwen topical
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0.05 % lotion
DesOwen topical
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0.05 % lotion

Copyright © 2010 First DataBank, Inc.

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Patient Handout

Patient Education
desonide topical

DESONIDE LOTION - TOPICAL

(DES-oh-nide)

COMMON BRAND NAME(S): Desowen

USES: This medication is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Desonide reduces the swelling, itching and redness that can occur in these types of conditions. Desonide is a mild corticosteroid.

HOW TO USE: Use this medication only on the skin.Shake the bottle well before using. Wash your hands. Clean and dry the affected area. Apply a thin film of medication to the affected area and gently rub in, usually 2-3 times daily, or as directed by your doctor. Do not bandage, wrap, or cover the area unless you are instructed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.After applying the medication, wash and dry your hands, unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes because this may worsen or cause glaucoma or cause irritation. Also, avoid getting this medication in the nose or mouth. If you get this medication in your eyes, nose, or mouth, rinse right away with plenty of water.Use this medication only for the condition prescribed.Inform your doctor if your condition persists or worsens after 2 weeks.

SIDE EFFECTS: Burning, stinging, itching, irritation, dryness, or redness may occur when first applied to the skin. This should disappear in a few days as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: stretch marks, skin thinning/discoloration, acne, excessive hair growth, hair bumps (folliculitis).Skin infections can become worse when using this medication. Notify your doctor promptly if redness, swelling or irritation does not improve.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using desonide, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (e.g., hydrocortisone, prednisone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, diabetes, immune system problems, other skin conditions (e.g., rosacea, perioral dermatitis).Do not use if there is an infection or sore in the area to be treated.Children may be more sensitive to the effects of too much corticosteroid medication. Consult your doctor for more details.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this medication, when applied to the skin, passes into breast milk. However, similar drugs, when taken by mouth, pass into breast milk. Consult your doctor before breast-feeding. If used during breastfeeding, avoid applying the medication to the breast/nipple area to prevent the infant from swallowing the medication.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: oral corticosteroids (e.g., prednisone), other topical corticosteroids (e.g., hydrocortisone), drugs that suppress the immune system (e.g., cyclosporine).

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. This medication may be harmful if swallowed.

NOTES: Do not share this medication with others. This medication has been prescribed for your current condition only. Do not use it later for other skin problems unless told to do so by your doctor. A different medication may be necessary in those cases.Inform all your doctors you use or have used this medication.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised September 2021. Copyright(c) 2021 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
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Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.