Coenzyme Q10 (Herb/Suppl)

Brand and Other Names:CoQ10, ibedenone, more...mitoquinone, ubidecarenone, ubiquinone, vitamin Q10
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Suggested Dosing

50-200 mg PO daily

CHF: 100 mg/day div BID-TID PO

Myocardial preservation for heart surgery: 200 mg/day PO

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Suggested Uses

Angina, chronic fatigue syndrome, CHF, diabetes mellitus, doxorubicin-induced cardiotoxicity (prevention), HIV/AIDS immunostimulant, hypertension, mitochondrial cytopathies, muscular dystrophies, myopathy (statin-induced)

Efficacy may be effective in CHF, MI, mitochondrial encephalomyopathies

Reduces BP; more studies need before recommendation in hypertension

Inconclusive for stable angina, cardiomyopathy, periodontal disease

Huntington Disease (Orphan)

Orphan indication sponsors

  • Integrative Therapeutics, Inc; 825 Challenger Drive; Green Bay , WI 54311
  • Gel-Tec, Division of Tishcon Corp; 30 New York Avenue; PO Box 331; Westbury, NY 11590

Mitochondrial Cytopathies (Orphan)

Orphan indication sponsor

  • Gel-Tec, Division of TISHCON Corporation; 30 New York Avenue; PO Box 331; Westbury, NY 11590

Pediatric Congestive Heart Failure (Orphan)

Orphan indication sponsor

  • Gel-Tec, Division of TISHCON Corporation; 30 New York Avenue; PO Box 331; Westbury, NY 11590

Epidermolysis Bullosa (Orphan)

Orphan designation of ubidecarenone for treatment of epidermolysis bullosa

Sponsor

  • Berg, LLC (BERG)l 500 Old Connecticut Path, Building B; Framingham, Massachusetts 01701
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Interactions

Interaction Checker

and Coenzyme Q10

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (1)

                • warfarin

                  coenzyme Q10 increases effects of warfarin by unspecified interaction mechanism. Use Caution/Monitor.

                Minor (16)

                • atorvastatin

                  atorvastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                • fluvastatin

                  fluvastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                • glyburide

                  glyburide decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                • insulin aspart

                  coenzyme Q10 increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                • insulin detemir

                  coenzyme Q10 increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                • insulin glargine

                  coenzyme Q10 increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                • insulin glulisine

                  coenzyme Q10 increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                • insulin lispro

                  coenzyme Q10 increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                • insulin NPH

                  coenzyme Q10 increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                • insulin regular human

                  coenzyme Q10 increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                • lovastatin

                  lovastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                • pitavastatin

                  pitavastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                • pravastatin

                  pravastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                • rosuvastatin

                  rosuvastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                • simvastatin

                  simvastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                • tolazamide

                  tolazamide decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

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                Adverse Effects

                Frequency Not Defined

                Diarrhea

                Appetite decreased

                Elevated LFTs

                Gastric distress

                Nausea

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                Warnings

                Cautions

                Biliary obstruction, concurrent antihypertensives, concurrent cancer chemotherapy, concurrent radiation therapy, hepatic insufficiency, hypertension

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                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Ubiquinone: involved in electron transport chain

                Ubiquinol: antioxidant, membrane stabilizer

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.