albuterol/ipratropium (Rx)

Chronic Obstructive Pulmonary Disease

Treatment of chronic obstructive pulmonary disease (COPD) in patients on regular bronchodilator who continue to have bronchospasm and require second bronchodilator

Aerosol: 100 mcg/20 mcg (1 actuation of metered-dose inhaler) q6hr; not to exceed 6 actuations/day

Nebulizer solution: 3 mL inhaled q6hr; not to exceed 3 mL q4hr

Dosing Considerations

Patients aged >65 years have higher steady-state systemic exposures for albuterol and ipratropium

Safety and efficacy not established

Contraindicated (4)

• cisapride

  albuterol and cisapride both increase QTc interval. Contraindicated.

• dronedarone

  albuterol and dronedarone both increase QTc interval. Contraindicated.

• saquinavir

  saquinavir, albuterol. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated. Contraindicated. Saquinavir boosted with ritonavir increases risk of hypokalemia, QT prolongation, and cardiac arrhythmias.

• thioridazine

  albuterol and thioridazine both increase QTc interval. Contraindicated.

Serious - Use Alternative (27)

• amitriptyline

  amitriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• amoxapine

  amoxapine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• azithromycin

  albuterol and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.

• clomipramine

  clomipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• desipramine

  desipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• doxepin

  doxepin, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• fexinidazole

  fexinidazole and albuterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.

• glucagon

  glucagon increases toxicity of ipratropium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .

• glucagon intranasal

  glucagon intranasal increases toxicity of ipratropium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .

• hydroxychloroquine sulfate

  albuterol and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.

• imipramine

  imipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• isocarboxazid

  isocarboxazid increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

• linezolid

  linezolid increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

• lofepramine

  lofepramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• lopinavir

  albuterol and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.

• macimorelin

  ipratropium, macimorelin. unspecified interaction mechanism. Avoid or Use Alternate Drug. Drugs that may blunt the growth hormone (GH) response to macrimorelin may impact the accuracy of the diagnostic test. Allow sufficient washout time of drugs affecting GH release before administering macimorelin.

• maprotiline

  maprotiline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• nortriptyline

  nortriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• phenelzine

  phenelzine increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

• pimozide

  albuterol and pimozide both increase QTc interval. Contraindicated.

• pramlintide

  pramlintide, ipratropium. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.

• protriptyline

  protriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• revefenacin

  revefenacin and ipratropium both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Coadministration may cause additive anticholinergic effects.

• tranylcypromine

  tranylcypromine increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

• trazodone

  trazodone, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• trimipramine

  trimipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• umeclidinium bromide/vilanterol inhaled

  ipratropium, umeclidinium bromide/vilanterol inhaled. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Concomitant use with other anticholinergic-containing drugs may lead to additive anticholinergic adverse effects.

Monitor Closely (397)

• abobotulinumtoxinA

  abobotulinumtoxinA increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .

• acebutolol

  acebutolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  acebutolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• aceclofenac

  aceclofenac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• acemetacin

  acemetacin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• aclidinium

  ipratropium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• alfentanil

  alfentanil increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• alprazolam

  alprazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• amantadine

  ipratropium, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.

• amiloride

  amiloride increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• amiodarone

  albuterol and amiodarone both increase QTc interval. Use Caution/Monitor.

• amisulpride

  albuterol and amisulpride both increase QTc interval. Use Caution/Monitor.
  
  amisulpride and albuterol both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended if coadministered.

• amitriptyline

  albuterol and amitriptyline both increase QTc interval. Use Caution/Monitor.
  
  ipratropium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  amitriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• amobarbital

  amobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• amoxapine

  ipratropium and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• amoxapine

  amoxapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• anagrelide

  albuterol and anagrelide both increase QTc interval. Use Caution/Monitor.

• anticholinergic/sedative combos

  anticholinergic/sedative combos and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• apomorphine

  albuterol and apomorphine both increase QTc interval. Use Caution/Monitor.

• arformoterol

  albuterol and arformoterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and arformoterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and arformoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• aripiprazole

  ipratropium decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  aripiprazole increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor.
  
  aripiprazole increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• armodafinil

  albuterol and armodafinil both decrease sedation. Use Caution/Monitor.

• atracurium

  atracurium and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• arsenic trioxide

  albuterol and arsenic trioxide both increase QTc interval. Use Caution/Monitor.

• artemether/lumefantrine

  albuterol and artemether/lumefantrine both increase QTc interval. Use Caution/Monitor.

• asenapine

  albuterol and asenapine both increase QTc interval. Use Caution/Monitor.

• aspirin

  aspirin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• aspirin rectal

  aspirin rectal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

• aspirin/citric acid/sodium bicarbonate

  aspirin/citric acid/sodium bicarbonate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• atenolol

  atenolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  atenolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• atomoxetine

  atomoxetine, albuterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of tachycardia, increased blood pressure.

• atropine

  atropine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• atropine IV/IM

  atropine IV/IM and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• azelastine

  azelastine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• bedaquiline

  albuterol and bedaquiline both increase QTc interval. Use Caution/Monitor.

• belladonna alkaloids

  belladonna alkaloids and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• belladonna and opium

  ipratropium and belladonna and opium both decrease cholinergic effects/transmission. Use Caution/Monitor.
  
  belladonna and opium increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• bendroflumethiazide

  albuterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.

• benperidol

  ipratropium decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  benperidol increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• benperidol

  benperidol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• benzphetamine

  albuterol and benzphetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• benztropine

  benztropine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use.

• betaxolol

  betaxolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  betaxolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• bethanechol

  bethanechol increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• bisoprolol

  bisoprolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  bisoprolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• brompheniramine

  brompheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• bumetanide

  albuterol and bumetanide both decrease serum potassium. Use Caution/Monitor.

• buprenorphine

  buprenorphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and buprenorphine both increase QTc interval. Use Caution/Monitor.

• buprenorphine buccal

  buprenorphine buccal increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• butabarbital

  butabarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• butalbital

  butalbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• butorphanol

  butorphanol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• caffeine

  albuterol and caffeine both decrease sedation. Use Caution/Monitor.

• carbachol

  carbachol increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• carbenoxolone

  albuterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.

• carbinoxamine

  carbinoxamine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• carvedilol

  carvedilol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  carvedilol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• celecoxib

  celecoxib increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• celiprolol

  celiprolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  celiprolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• cevimeline

  cevimeline increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• chloral hydrate

  chloral hydrate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• chlordiazepoxide

  chlordiazepoxide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• chloroquine

  albuterol and chloroquine both increase QTc interval. Use Caution/Monitor.

• chlorothiazide

  albuterol and chlorothiazide both decrease serum potassium. Use Caution/Monitor.

• chlorpheniramine

  chlorpheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• chlorpromazine

  chlorpromazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  chlorpromazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  albuterol and chlorpromazine both increase QTc interval. Use Caution/Monitor.

• chlorthalidone

  albuterol and chlorthalidone both decrease serum potassium. Use Caution/Monitor.

• cisatracurium

  cisatracurium and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• choline magnesium trisalicylate

  choline magnesium trisalicylate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

• cinnarizine

  cinnarizine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ciprofloxacin

  albuterol and ciprofloxacin both increase QTc interval. Use Caution/Monitor.

• citalopram

  albuterol and citalopram both increase QTc interval. Use Caution/Monitor.

• clarithromycin

  albuterol and clarithromycin both increase QTc interval. Use Caution/Monitor.

• clemastine

  clemastine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• clomipramine

  clomipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• clonazepam

  clonazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• clozapine

  ipratropium decreases levels of clozapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  clozapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• clorazepate

  clorazepate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• clozapine

  clozapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and clozapine both increase QTc interval. Use Caution/Monitor.

• codeine

  codeine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• crizotinib

  albuterol and crizotinib both increase QTc interval. Use Caution/Monitor.

• cyclizine

  cyclizine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  cyclizine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• cyclobenzaprine

  cyclobenzaprine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• cyclopenthiazide

  albuterol and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.

• cyproheptadine

  cyproheptadine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• darifenacin

  darifenacin and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• dasatinib

  albuterol and dasatinib both increase QTc interval. Use Caution/Monitor.

• deflazacort

  albuterol and deflazacort both decrease serum potassium. Use Caution/Monitor.

• degarelix

  albuterol and degarelix both increase QTc interval. Use Caution/Monitor.

• desipramine

  desipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  albuterol and desipramine both increase QTc interval. Use Caution/Monitor.

• deutetrabenazine

  albuterol and deutetrabenazine both increase QTc interval. Use Caution/Monitor.

• dicyclomine

  dicyclomine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• dexchlorpheniramine

  dexchlorpheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dexfenfluramine

  albuterol and dexfenfluramine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dexmedetomidine

  dexmedetomidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dexmethylphenidate

  albuterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor.
  
  albuterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dextroamphetamine

  albuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dextromoramide

  dextromoramide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• diamorphine

  diamorphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dichlorphenamide

  dichlorphenamide and albuterol both decrease serum potassium. Use Caution/Monitor.
  
  dichlorphenamide, albuterol. Either increases levels of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.

• diclofenac

  diclofenac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• diethylpropion

  albuterol and diethylpropion both decrease sedation. Use Caution/Monitor.
  
  albuterol and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• difenoxin hcl

  difenoxin hcl increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• diflunisal

  diflunisal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• digoxin

  digoxin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dimenhydrinate

  dimenhydrinate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• diphenhydramine

  diphenhydramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  diphenhydramine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• diphenoxylate hcl

  diphenoxylate hcl increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• donepezil

  donepezil increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dipipanone

  dipipanone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• disopyramide

  albuterol and disopyramide both increase QTc interval. Use Caution/Monitor.

• dobutamine

  albuterol and dobutamine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and dobutamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dobutamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dolasetron

  albuterol and dolasetron both increase QTc interval. Use Caution/Monitor.

• donepezil

  donepezil and albuterol both increase QTc interval. Use Caution/Monitor.

• donepezil transdermal

  donepezil transdermal, ipratropium. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.

• dopamine

  albuterol and dopamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dopexamine

  albuterol and dopexamine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and dopexamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dopexamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  
  dopexamine, albuterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.

• dosulepin

  ipratropium and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.

• doxepin

  doxepin and albuterol both increase QTc interval. Use Caution/Monitor.
  
  doxepin increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• droperidol

  albuterol and droperidol both increase QTc interval. Use Caution/Monitor.
  
  ipratropium decreases levels of droperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  droperidol increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  droperidol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor.

• drospirenone

  drospirenone increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• echothiophate iodide

  echothiophate iodide increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• efavirenz

  efavirenz and albuterol both increase QTc interval. Use Caution/Monitor.

• encorafenib

  albuterol and encorafenib both increase QTc interval. Use Caution/Monitor.

• entrectinib

  albuterol and entrectinib both increase QTc interval. Use Caution/Monitor.

• ephedrine

  albuterol and ephedrine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and ephedrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and ephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• epinephrine

  albuterol and epinephrine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and epinephrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• epinephrine racemic

  albuterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and epinephrine racemic both decrease sedation. Use Caution/Monitor.
  
  albuterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• eribulin

  albuterol and eribulin both increase QTc interval. Use Caution/Monitor.

• erythromycin base

  albuterol and erythromycin base both increase QTc interval. Use Caution/Monitor.

• erythromycin ethylsuccinate

  albuterol and erythromycin ethylsuccinate both increase QTc interval. Use Caution/Monitor.

• erythromycin lactobionate

  albuterol and erythromycin lactobionate both increase QTc interval. Use Caution/Monitor.

• erythromycin stearate

  albuterol and erythromycin stearate both increase QTc interval. Use Caution/Monitor.

• escitalopram

  albuterol and escitalopram both increase QTc interval. Use Caution/Monitor.

• esmolol

  esmolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  esmolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• estazolam

  estazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ethacrynic acid

  albuterol and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.

• ethanol

  ethanol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• etodolac

  etodolac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• fenfluramine

  albuterol and fenfluramine both decrease sedation. Use Caution/Monitor.
  
  albuterol and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• fenoprofen

  fenoprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• fesoterodine

  fesoterodine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• fexinidazole

  albuterol and fexinidazole both increase QTc interval. Use Caution/Monitor.

• fingolimod

  fingolimod and albuterol both increase QTc interval. Use Caution/Monitor.

• flavoxate

  flavoxate and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• flecainide

  albuterol and flecainide both increase QTc interval. Use Caution/Monitor.

• fluconazole

  albuterol and fluconazole both increase QTc interval. Use Caution/Monitor.

• fluoxetine

  albuterol and fluoxetine both increase QTc interval. Use Caution/Monitor.

• fluphenazine

  albuterol and fluphenazine both increase QTc interval. Use Caution/Monitor.
  
  fluphenazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  fluphenazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

• flurazepam

  flurazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• galantamine

  galantamine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• flurbiprofen

  flurbiprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• formoterol

  albuterol and formoterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and formoterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• foscarnet

  albuterol and foscarnet both increase QTc interval. Use Caution/Monitor.

• fostemsavir

  albuterol and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.

• furosemide

  albuterol and furosemide both decrease serum potassium. Use Caution/Monitor.

• gemifloxacin

  albuterol and gemifloxacin both increase QTc interval. Use Caution/Monitor.

• gemtuzumab

  albuterol and gemtuzumab both increase QTc interval. Use Caution/Monitor.

• gentamicin

  albuterol and gentamicin both decrease serum potassium. Use Caution/Monitor.

• gilteritinib

  albuterol and gilteritinib both increase QTc interval. Use Caution/Monitor.

• glasdegib

  albuterol and glasdegib both increase QTc interval. Use Caution/Monitor.

• glycopyrrolate

  glycopyrrolate and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• glycopyrrolate inhaled

  glycopyrrolate inhaled and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• glycopyrronium tosylate topical

  glycopyrronium tosylate topical, ipratropium. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.

• goserelin

  albuterol and goserelin both increase QTc interval. Use Caution/Monitor.

• granisetron

  albuterol and granisetron both increase QTc interval. Use Caution/Monitor.

• green tea

  green tea increases effects of albuterol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

• haloperidol

  albuterol and haloperidol both increase QTc interval. Use Caution/Monitor.
  
  ipratropium decreases levels of haloperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  haloperidol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of haloperidol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  haloperidol increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• henbane

  henbane and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• histrelin

  albuterol and histrelin both increase QTc interval. Use Caution/Monitor.

• homatropine

  homatropine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• huperzine A

  huperzine A increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• hydrochlorothiazide

  albuterol and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.

• hydromorphone

  hydromorphone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• hydroxyzine

  hydroxyzine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• hyoscyamine

  hyoscyamine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• hyoscyamine spray

  hyoscyamine spray and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• ibuprofen

  ibuprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ibuprofen IV

  ibuprofen IV increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ibutilide

  albuterol and ibutilide both increase QTc interval. Use Caution/Monitor.

• iloperidone

  iloperidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of iloperidone by pharmacodynamic antagonism. Use Caution/Monitor.
  
  ipratropium decreases levels of iloperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  iloperidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  albuterol and iloperidone both increase QTc interval. Use Caution/Monitor.

• imipramine

  ipratropium and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  imipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• indapamide

  albuterol and indapamide both decrease serum potassium. Use Caution/Monitor.

• lofepramine

  ipratropium and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor.

• indomethacin

  indomethacin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• inotuzumab

  albuterol and inotuzumab both increase QTc interval. Use Caution/Monitor.

• irbesartan

  irbesartan increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• isoflurane

  albuterol and isoflurane both increase QTc interval. Use Caution/Monitor.

• isoproterenol

  albuterol and isoproterenol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and isoproterenol both decrease sedation. Use Caution/Monitor.
  
  albuterol and isoproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• itraconazole

  albuterol and itraconazole both increase QTc interval. Use Caution/Monitor.

• ivosidenib

  albuterol and ivosidenib both increase QTc interval. Use Caution/Monitor.

• ketoprofen

  ketoprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ketorolac

  ketorolac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ketorolac intranasal

  ketorolac intranasal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

• ketotifen, ophthalmic

  ketotifen, ophthalmic increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• labetalol

  labetalol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  labetalol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• lapatinib

  albuterol and lapatinib both increase QTc interval. Use Caution/Monitor.

• lefamulin

  albuterol and lefamulin both increase QTc interval. Use Caution/Monitor.

• lenvatinib

  albuterol and lenvatinib both increase QTc interval. Use Caution/Monitor.

• leuprolide

  albuterol and leuprolide both increase QTc interval. Use Caution/Monitor.

• levalbuterol

  albuterol and levalbuterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and levalbuterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and levalbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• levofloxacin

  albuterol and levofloxacin both increase QTc interval. Use Caution/Monitor.

• levorphanol

  levorphanol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lisdexamfetamine

  albuterol and lisdexamfetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• lithium

  albuterol and lithium both increase QTc interval. Use Caution/Monitor.

• lofepramine

  lofepramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lofexidine

  lofexidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and lofexidine both increase QTc interval. Use Caution/Monitor.

• loperamide

  albuterol and loperamide both increase QTc interval. Use Caution/Monitor.

• loprazolam

  loprazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lorazepam

  lorazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lormetazepam

  lormetazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lornoxicam

  lornoxicam increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• loxapine

  loxapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of loxapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  loxapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of loxapine by pharmacodynamic antagonism. Use Caution/Monitor.

• loxapine inhaled

  loxapine inhaled increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  loxapine inhaled increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of loxapine inhaled by pharmacodynamic antagonism. Use Caution/Monitor.

• maprotiline

  albuterol and maprotiline both increase QTc interval. Use Caution/Monitor.
  
  ipratropium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  maprotiline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• marijuana

  marijuana increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• meclizine

  ipratropium and meclizine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• meclofenamate

  meclofenamate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• mefenamic acid

  mefenamic acid increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• mefloquine

  albuterol and mefloquine both increase QTc interval. Use Caution/Monitor.

• melatonin

  melatonin increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• meloxicam

  meloxicam increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• meperidine

  meperidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• meprobamate

  meprobamate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• metaproterenol

  albuterol and metaproterenol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and metaproterenol both decrease sedation. Use Caution/Monitor.
  
  albuterol and metaproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• methadone

  methadone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and methadone both increase QTc interval. Use Caution/Monitor.

• methamphetamine

  albuterol and methamphetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• methscopolamine

  ipratropium and methscopolamine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• methyclothiazide

  albuterol and methyclothiazide both decrease serum potassium. Use Caution/Monitor.

• methylenedioxymethamphetamine

  albuterol and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• methylphenidate

  albuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• metolazone

  albuterol and metolazone both decrease serum potassium. Use Caution/Monitor.

• metoprolol

  metoprolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  metoprolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• midazolam

  midazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• midodrine

  albuterol and midodrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• mifepristone

  albuterol and mifepristone both increase QTc interval. Use Caution/Monitor.

• mirtazapine

  mirtazapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and mirtazapine both increase QTc interval. Use Caution/Monitor.

• modafinil

  albuterol and modafinil both decrease sedation. Use Caution/Monitor.

• morphine

  morphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• motherwort

  motherwort increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• moxifloxacin

  albuterol and moxifloxacin both increase QTc interval. Use Caution/Monitor.

• moxonidine

  moxonidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nabilone

  nabilone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nabumetone

  nabumetone increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nadolol

  nadolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  nadolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• nalbuphine

  nalbuphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• naproxen

  naproxen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nebivolol

  nebivolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  nebivolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• neostigmine

  neostigmine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nilotinib

  albuterol and nilotinib both increase QTc interval. Use Caution/Monitor.

• norepinephrine

  albuterol and norepinephrine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and norepinephrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and norepinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• nortriptyline

  albuterol and nortriptyline both increase QTc interval. Use Caution/Monitor.
  
  nortriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• octreotide

  albuterol and octreotide both increase QTc interval. Use Caution/Monitor.

• olanzapine

  ipratropium decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  olanzapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• ofloxacin

  albuterol and ofloxacin both increase QTc interval. Use Caution/Monitor.

• olanzapine

  olanzapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances

• olodaterol inhaled

  albuterol and olodaterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effects
  
  albuterol and olodaterol inhaled both increase QTc interval. Use Caution/Monitor.

• onabotulinumtoxinA

  onabotulinumtoxinA and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• ondansetron

  albuterol and ondansetron both increase QTc interval. Use Caution/Monitor.

• opium tincture

  opium tincture increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• orphenadrine

  ipratropium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.

• osilodrostat

  osilodrostat and albuterol both increase QTc interval. Use Caution/Monitor.
  
  albuterol and osilodrostat both increase QTc interval. Use Caution/Monitor. Dose dependent QT prolongation - avoid drugs known to prolong the QT interval

• osimertinib

  albuterol and osimertinib both increase QTc interval. Use Caution/Monitor.

• oxaliplatin

  oxaliplatin will increase the level or effect of albuterol by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.
  
  albuterol and oxaliplatin both increase QTc interval. Use Caution/Monitor.

• oxaprozin

  oxaprozin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• oxazepam

  oxazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• oxybutynin

  ipratropium and oxybutynin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• oxybutynin topical

  ipratropium and oxybutynin topical both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• oxybutynin transdermal

  ipratropium and oxybutynin transdermal both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• oxycodone

  oxycodone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• oxymorphone

  oxymorphone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ozanimod

  albuterol and ozanimod both increase QTc interval. Use Caution/Monitor.

• paliperidone

  albuterol and paliperidone both increase QTc interval. Use Caution/Monitor.
  
  paliperidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  paliperidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of paliperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor.

• pancuronium

  ipratropium and pancuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• panobinostat

  albuterol and panobinostat both increase QTc interval. Use Caution/Monitor.

• papaveretum

  papaveretum increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• papaverine

  papaverine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• parecoxib

  parecoxib increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pasireotide

  albuterol and pasireotide both increase QTc interval. Use Caution/Monitor.

• pazopanib

  albuterol and pazopanib both increase QTc interval. Use Caution/Monitor.

• penbutolol

  penbutolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  penbutolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• pentamidine

  albuterol and pentamidine both increase QTc interval. Use Caution/Monitor.

• pentazocine

  pentazocine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pentobarbital

  pentobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• perphenazine

  ipratropium decreases levels of perphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  perphenazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of perphenazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  perphenazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• phendimetrazine

  albuterol and phendimetrazine both decrease sedation. Use Caution/Monitor.
  
  albuterol and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• physostigmine

  physostigmine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• phenobarbital

  phenobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• phenoxybenzamine

  phenoxybenzamine, albuterol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Hypotension, tachycardia.

• phentermine

  albuterol and phentermine both decrease sedation. Use Caution/Monitor.
  
  albuterol and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• phenylephrine

  albuterol and phenylephrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• phenylephrine PO

  albuterol and phenylephrine PO both decrease sedation. Use Caution/Monitor.
  
  albuterol and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• pholcodine

  pholcodine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pilocarpine

  pilocarpine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pimavanserin

  albuterol and pimavanserin both increase QTc interval. Use Caution/Monitor.

• pimozide

  pimozide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.
  
  ipratropium decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  pimozide increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• pindolol

  pindolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  pindolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• pralidoxime

  ipratropium and pralidoxime both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• pirbuterol

  albuterol and pirbuterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and pirbuterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• piroxicam

  piroxicam increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pitolisant

  albuterol and pitolisant both increase QTc interval. Use Caution/Monitor.

• ponesimod

  albuterol and ponesimod both increase QTc interval. Use Caution/Monitor.

• posaconazole

  albuterol and posaconazole both increase QTc interval. Use Caution/Monitor.

• potassium acid phosphate

  potassium acid phosphate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• potassium chloride

  potassium chloride increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• primaquine

  albuterol and primaquine both increase QTc interval. Use Caution/Monitor.

• primidone

  primidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• procainamide

  albuterol and procainamide both increase QTc interval. Use Caution/Monitor.

• procarbazine

  procarbazine increases effects of albuterol by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

• prochlorperazine

  prochlorperazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  prochlorperazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

• promethazine

  ipratropium decreases levels of promethazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  promethazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  promethazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• propafenone

  albuterol and propafenone both increase QTc interval. Use Caution/Monitor.

• propantheline

  ipratropium and propantheline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• propranolol

  propranolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  propranolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• propylhexedrine

  albuterol and propylhexedrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and propylhexedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• protriptyline

  protriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and protriptyline both increase QTc interval. Use Caution/Monitor.
  
  ipratropium and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.

• pseudoephedrine

  albuterol and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• pyridostigmine

  pyridostigmine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• quazepam

  quazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• quetiapine

  ipratropium decreases levels of quetiapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  quetiapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  albuterol and quetiapine both increase QTc interval. Use Caution/Monitor.
  
  quetiapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of quetiapine by pharmacodynamic antagonism. Use Caution/Monitor.

• quinidine

  albuterol and quinidine both increase QTc interval. Use Caution/Monitor.

• rapacuronium

  ipratropium and rapacuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• quinine

  albuterol and quinine both increase QTc interval. Use Caution/Monitor.

• ranolazine

  albuterol and ranolazine both increase QTc interval. Use Caution/Monitor.

• ribociclib

  albuterol and ribociclib both increase QTc interval. Use Caution/Monitor.

• rilpivirine

  albuterol and rilpivirine both increase QTc interval. Use Caution/Monitor.

• risperidone

  albuterol and risperidone both increase QTc interval. Use Caution/Monitor.
  
  risperidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  risperidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• rocuronium

  ipratropium and rocuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• romidepsin

  albuterol and romidepsin both increase QTc interval. Use Caution/Monitor.

• sacubitril/valsartan

  sacubitril/valsartan increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• salicylates (non-asa)

  salicylates (non-asa) increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• salmeterol

  albuterol and salmeterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and salmeterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and salmeterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• salsalate

  salsalate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• saquinavir

  albuterol and saquinavir both increase QTc interval. Use Caution/Monitor.

• scopolamine

  ipratropium and scopolamine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• scullcap

  scullcap increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• secobarbital

  secobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• selpercatinib

  albuterol and selpercatinib both increase QTc interval. Use Caution/Monitor.

• serdexmethylphenidate/dexmethylphenidate

  albuterol and serdexmethylphenidate/dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• sertraline

  albuterol and sertraline both increase QTc interval. Use Caution/Monitor.

• sevoflurane

  albuterol and sevoflurane both increase QTc interval. Use Caution/Monitor.

• shepherd's purse

  shepherd's purse increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• siponimod

  albuterol and siponimod both increase QTc interval. Use Caution/Monitor.

• sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol

  albuterol and sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol both decrease serum potassium. Modify Therapy/Monitor Closely.

• solifenacin

  ipratropium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  albuterol and solifenacin both increase QTc interval. Use Caution/Monitor.

• solriamfetol

  albuterol and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• succinylcholine

  succinylcholine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sorafenib

  albuterol and sorafenib both increase QTc interval. Use Caution/Monitor.

• sotalol

  sotalol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  sotalol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  albuterol and sotalol both increase QTc interval. Use Caution/Monitor.

• spironolactone

  spironolactone increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• succinylcholine

  succinylcholine increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sufentanil

  sufentanil increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sulfasalazine

  sulfasalazine increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sulindac

  sulindac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sunitinib

  albuterol and sunitinib both increase QTc interval. Use Caution/Monitor.

• tacrolimus

  albuterol and tacrolimus both increase QTc interval. Use Caution/Monitor.

• tapentadol

  tapentadol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• telavancin

  albuterol and telavancin both increase QTc interval. Use Caution/Monitor.

• temazepam

  temazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• terbutaline

  albuterol and terbutaline both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and terbutaline both decrease sedation. Use Caution/Monitor.
  
  albuterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• tetrabenazine

  albuterol and tetrabenazine both increase QTc interval. Use Caution/Monitor.

• thioridazine

  thioridazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of thioridazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  thioridazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of thioridazine by pharmacodynamic antagonism. Use Caution/Monitor.

• thiothixene

  thiothixene increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor.
  
  thiothixene increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

• timolol

  timolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  timolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

• tiotropium

  ipratropium and tiotropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• tolfenamic acid

  tolfenamic acid increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• tolmetin

  tolmetin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• tolterodine

  ipratropium and tolterodine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• tolvaptan

  tolvaptan increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• topiramate

  topiramate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• toremifene

  albuterol and toremifene both increase QTc interval. Use Caution/Monitor.

• torsemide

  albuterol and torsemide both decrease serum potassium. Use Caution/Monitor.

• tramadol

  tramadol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• trazodone

  trazodone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and trazodone both increase QTc interval. Use Caution/Monitor.
  
  ipratropium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.

• triamterene

  triamterene increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• trifluoperazine

  ipratropium decreases levels of trifluoperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of trifluoperazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  trifluoperazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• triazolam

  triazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• triclabendazole

  albuterol and triclabendazole both increase QTc interval. Use Caution/Monitor.

• triclofos

  triclofos increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• trifluoperazine

  trifluoperazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• trihexyphenidyl

  ipratropium and trihexyphenidyl both decrease cholinergic effects/transmission. Use Caution/Monitor. Potential for additive anticholinergic effects.

• trimipramine

  albuterol and trimipramine both increase QTc interval. Use Caution/Monitor.
  
  trimipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• triprolidine

  triprolidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• trospium chloride

  ipratropium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• triptorelin

  albuterol and triptorelin both increase QTc interval. Use Caution/Monitor.

• umeclidinium bromide

  umeclidinium bromide and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. If possible, avoid coadministration of additional anticholinergic agents

• vandetanib

  albuterol and vandetanib both increase QTc interval. Use Caution/Monitor.

• vardenafil

  albuterol and vardenafil both increase QTc interval. Use Caution/Monitor.

• vecuronium

  ipratropium and vecuronium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• vemurafenib

  albuterol and vemurafenib both increase QTc interval. Use Caution/Monitor.

• voclosporin

  albuterol and voclosporin both increase QTc interval. Use Caution/Monitor.

• voriconazole

  albuterol and voriconazole both increase QTc interval. Use Caution/Monitor.

• vorinostat

  albuterol and vorinostat both increase QTc interval. Use Caution/Monitor.

• xylometazoline

  albuterol and xylometazoline both decrease sedation. Use Caution/Monitor.
  
  albuterol and xylometazoline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• yohimbine

  albuterol and yohimbine both decrease sedation. Use Caution/Monitor.
  
  albuterol and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• ziconotide

  ziconotide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ziprasidone

  ziprasidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ziprasidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  albuterol and ziprasidone both increase QTc interval. Use Caution/Monitor.
  
  ipratropium decreases levels of ziprasidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of ziprasidone by pharmacodynamic antagonism. Use Caution/Monitor.

• zotepine

  ipratropium decreases levels of zotepine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of zotepine by pharmacodynamic antagonism. Use Caution/Monitor.

Minor (15)

• bendroflumethiazide

  albuterol, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• bumetanide

  albuterol, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• chlorothiazide

  albuterol, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• chlorthalidone

  albuterol, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• cyclopenthiazide

  albuterol, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• dimenhydrinate

  dimenhydrinate increases toxicity of ipratropium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

• donepezil

  donepezil decreases effects of ipratropium by pharmacodynamic antagonism. Minor/Significance Unknown.

• ethacrynic acid

  albuterol, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• eucalyptus

  eucalyptus increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

• furosemide

  albuterol, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• galantamine

  galantamine decreases effects of ipratropium by pharmacodynamic antagonism. Minor/Significance Unknown.

• hydrochlorothiazide

  albuterol, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• indapamide

  albuterol, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• levodopa

  ipratropium, levodopa. Other (see comment). Minor/Significance Unknown. Comment: Anticholinergic agents may enhance the therapeutic effects of levodopa; however, anticholinergic agents can exacerbate tardive dyskinesia. In high dosage, anticholinergics may decrease the effects of levodopa by delaying its GI absorption. .

• methyclothiazide

  albuterol, methyclothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• abobotulinumtoxinA

  Monitor Closely (1)abobotulinumtoxinA increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .

• acebutolol

  Monitor Closely (2)acebutolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  acebutolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• aceclofenac

  Monitor Closely (1)aceclofenac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• acemetacin

  Monitor Closely (1)acemetacin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• aclidinium

  Monitor Closely (1)ipratropium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• alfentanil

  Monitor Closely (1)alfentanil increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• alprazolam

  Monitor Closely (1)alprazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• amantadine

  Monitor Closely (1)ipratropium, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.

• amiloride

  Monitor Closely (1)amiloride increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• amiodarone

  Monitor Closely (1)albuterol and amiodarone both increase QTc interval. Use Caution/Monitor.

• amisulpride

  Monitor Closely (2)amisulpride and albuterol both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended if coadministered.
  
  albuterol and amisulpride both increase QTc interval. Use Caution/Monitor.

• amitriptyline

  Monitor Closely (3)albuterol and amitriptyline both increase QTc interval. Use Caution/Monitor.
  
  ipratropium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  amitriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amitriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• amobarbital

  Monitor Closely (1)amobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• amoxapine

  Monitor Closely (2)ipratropium and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  amoxapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• anagrelide

  Monitor Closely (1)albuterol and anagrelide both increase QTc interval. Use Caution/Monitor.

• anticholinergic/sedative combos

  Monitor Closely (1)anticholinergic/sedative combos and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• apomorphine

  Monitor Closely (1)albuterol and apomorphine both increase QTc interval. Use Caution/Monitor.

• arformoterol

  Monitor Closely (3)albuterol and arformoterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and arformoterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and arformoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• aripiprazole

  Monitor Closely (4)ipratropium decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  aripiprazole increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor.
  
  aripiprazole increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• armodafinil

  Monitor Closely (1)albuterol and armodafinil both decrease sedation. Use Caution/Monitor.

• arsenic trioxide

  Monitor Closely (1)albuterol and arsenic trioxide both increase QTc interval. Use Caution/Monitor.

• artemether/lumefantrine

  Monitor Closely (1)albuterol and artemether/lumefantrine both increase QTc interval. Use Caution/Monitor.

• asenapine

  Monitor Closely (1)albuterol and asenapine both increase QTc interval. Use Caution/Monitor.

• aspirin

  Monitor Closely (1)aspirin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• aspirin rectal

  Monitor Closely (1)aspirin rectal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

• aspirin/citric acid/sodium bicarbonate

  Monitor Closely (1)aspirin/citric acid/sodium bicarbonate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• atenolol

  Monitor Closely (2)atenolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  atenolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• atomoxetine

  Monitor Closely (1)atomoxetine, albuterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of tachycardia, increased blood pressure.

• atracurium

  Monitor Closely (1)atracurium and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• atropine

  Monitor Closely (1)atropine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• atropine IV/IM

  Monitor Closely (1)atropine IV/IM and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• azelastine

  Monitor Closely (1)azelastine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• azithromycin

  Serious - Use Alternative (1)albuterol and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.

• bedaquiline

  Monitor Closely (1)albuterol and bedaquiline both increase QTc interval. Use Caution/Monitor.

• belladonna alkaloids

  Monitor Closely (1)belladonna alkaloids and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• belladonna and opium

  Monitor Closely (2)ipratropium and belladonna and opium both decrease cholinergic effects/transmission. Use Caution/Monitor.
  
  belladonna and opium increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• bendroflumethiazide

  Monitor Closely (1)albuterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• benperidol

  Monitor Closely (4)benperidol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  ipratropium decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  benperidol increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• benzphetamine

  Monitor Closely (2)albuterol and benzphetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• benztropine

  Monitor Closely (1)benztropine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use.

• betaxolol

  Monitor Closely (2)betaxolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  betaxolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• bethanechol

  Monitor Closely (1)bethanechol increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• bisoprolol

  Monitor Closely (2)bisoprolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  bisoprolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• brompheniramine

  Monitor Closely (1)brompheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• bumetanide

  Monitor Closely (1)albuterol and bumetanide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• buprenorphine

  Monitor Closely (2)buprenorphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and buprenorphine both increase QTc interval. Use Caution/Monitor.

• buprenorphine buccal

  Monitor Closely (1)buprenorphine buccal increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• butabarbital

  Monitor Closely (1)butabarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• butalbital

  Monitor Closely (1)butalbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• butorphanol

  Monitor Closely (1)butorphanol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• caffeine

  Monitor Closely (1)albuterol and caffeine both decrease sedation. Use Caution/Monitor.

• carbachol

  Monitor Closely (1)carbachol increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• carbenoxolone

  Monitor Closely (1)albuterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.

• carbinoxamine

  Monitor Closely (1)carbinoxamine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• carvedilol

  Monitor Closely (2)carvedilol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  carvedilol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• celecoxib

  Monitor Closely (1)celecoxib increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• celiprolol

  Monitor Closely (2)celiprolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  celiprolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• cevimeline

  Monitor Closely (1)cevimeline increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• chloral hydrate

  Monitor Closely (1)chloral hydrate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• chlordiazepoxide

  Monitor Closely (1)chlordiazepoxide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• chloroquine

  Monitor Closely (1)albuterol and chloroquine both increase QTc interval. Use Caution/Monitor.

• chlorothiazide

  Monitor Closely (1)albuterol and chlorothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• chlorpheniramine

  Monitor Closely (1)chlorpheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• chlorpromazine

  Monitor Closely (5)chlorpromazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  chlorpromazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  albuterol and chlorpromazine both increase QTc interval. Use Caution/Monitor.

• chlorthalidone

  Monitor Closely (1)albuterol and chlorthalidone both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• choline magnesium trisalicylate

  Monitor Closely (1)choline magnesium trisalicylate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

• cinnarizine

  Monitor Closely (1)cinnarizine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ciprofloxacin

  Monitor Closely (1)albuterol and ciprofloxacin both increase QTc interval. Use Caution/Monitor.

• cisapride

  Contraindicated (1)albuterol and cisapride both increase QTc interval. Contraindicated.

• cisatracurium

  Monitor Closely (1)cisatracurium and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• citalopram

  Monitor Closely (1)albuterol and citalopram both increase QTc interval. Use Caution/Monitor.

• clarithromycin

  Monitor Closely (1)albuterol and clarithromycin both increase QTc interval. Use Caution/Monitor.

• clemastine

  Monitor Closely (1)clemastine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• clomipramine

  Monitor Closely (2)clomipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.Serious - Use Alternative (1)clomipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• clonazepam

  Monitor Closely (1)clonazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• clorazepate

  Monitor Closely (1)clorazepate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• clozapine

  Monitor Closely (5)ipratropium decreases levels of clozapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  albuterol and clozapine both increase QTc interval. Use Caution/Monitor.
  
  clozapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  clozapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• codeine

  Monitor Closely (1)codeine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• crizotinib

  Monitor Closely (1)albuterol and crizotinib both increase QTc interval. Use Caution/Monitor.

• cyclizine

  Monitor Closely (2)cyclizine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  cyclizine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• cyclobenzaprine

  Monitor Closely (1)cyclobenzaprine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• cyclopenthiazide

  Monitor Closely (1)albuterol and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• cyproheptadine

  Monitor Closely (1)cyproheptadine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• darifenacin

  Monitor Closely (1)darifenacin and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• dasatinib

  Monitor Closely (1)albuterol and dasatinib both increase QTc interval. Use Caution/Monitor.

• deflazacort

  Monitor Closely (1)albuterol and deflazacort both decrease serum potassium. Use Caution/Monitor.

• degarelix

  Monitor Closely (1)albuterol and degarelix both increase QTc interval. Use Caution/Monitor.

• desipramine

  Monitor Closely (3)desipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  albuterol and desipramine both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)desipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• deutetrabenazine

  Monitor Closely (1)albuterol and deutetrabenazine both increase QTc interval. Use Caution/Monitor.

• dexchlorpheniramine

  Monitor Closely (1)dexchlorpheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dexfenfluramine

  Monitor Closely (2)albuterol and dexfenfluramine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dexmedetomidine

  Monitor Closely (1)dexmedetomidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dexmethylphenidate

  Monitor Closely (2)albuterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor.
  
  albuterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dextroamphetamine

  Monitor Closely (2)albuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dextromoramide

  Monitor Closely (1)dextromoramide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• diamorphine

  Monitor Closely (1)diamorphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dichlorphenamide

  Monitor Closely (2)dichlorphenamide and albuterol both decrease serum potassium. Use Caution/Monitor.
  
  dichlorphenamide, albuterol. Either increases levels of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.

• diclofenac

  Monitor Closely (1)diclofenac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dicyclomine

  Monitor Closely (1)dicyclomine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• diethylpropion

  Monitor Closely (2)albuterol and diethylpropion both decrease sedation. Use Caution/Monitor.
  
  albuterol and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• difenoxin hcl

  Monitor Closely (1)difenoxin hcl increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• diflunisal

  Monitor Closely (1)diflunisal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• digoxin

  Monitor Closely (1)digoxin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dimenhydrinate

  Monitor Closely (1)dimenhydrinate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)dimenhydrinate increases toxicity of ipratropium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

• diphenhydramine

  Monitor Closely (2)diphenhydramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  diphenhydramine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• diphenoxylate hcl

  Monitor Closely (1)diphenoxylate hcl increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dipipanone

  Monitor Closely (1)dipipanone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• disopyramide

  Monitor Closely (1)albuterol and disopyramide both increase QTc interval. Use Caution/Monitor.

• dobutamine

  Monitor Closely (3)albuterol and dobutamine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and dobutamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dobutamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dolasetron

  Monitor Closely (1)albuterol and dolasetron both increase QTc interval. Use Caution/Monitor.

• donepezil

  Monitor Closely (2)donepezil and albuterol both increase QTc interval. Use Caution/Monitor.
  
  donepezil increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)donepezil decreases effects of ipratropium by pharmacodynamic antagonism. Minor/Significance Unknown.

• donepezil transdermal

  Monitor Closely (1)donepezil transdermal, ipratropium. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.

• dopamine

  Monitor Closely (2)albuterol and dopamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dopexamine

  Monitor Closely (4)dopexamine, albuterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.
  
  albuterol and dopexamine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and dopexamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and dopexamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• dosulepin

  Monitor Closely (1)ipratropium and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.

• doxepin

  Monitor Closely (3)doxepin and albuterol both increase QTc interval. Use Caution/Monitor.
  
  doxepin increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.Serious - Use Alternative (1)doxepin, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• dronedarone

  Contraindicated (1)albuterol and dronedarone both increase QTc interval. Contraindicated.

• droperidol

  Monitor Closely (5)albuterol and droperidol both increase QTc interval. Use Caution/Monitor.
  
  ipratropium decreases levels of droperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  droperidol increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  droperidol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor.

• drospirenone

  Monitor Closely (1)drospirenone increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• echothiophate iodide

  Monitor Closely (1)echothiophate iodide increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• efavirenz

  Monitor Closely (1)efavirenz and albuterol both increase QTc interval. Use Caution/Monitor.

• encorafenib

  Monitor Closely (1)albuterol and encorafenib both increase QTc interval. Use Caution/Monitor.

• entrectinib

  Monitor Closely (1)albuterol and entrectinib both increase QTc interval. Use Caution/Monitor.

• ephedrine

  Monitor Closely (3)albuterol and ephedrine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and ephedrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and ephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• epinephrine

  Monitor Closely (3)albuterol and epinephrine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and epinephrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• epinephrine racemic

  Monitor Closely (3)albuterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and epinephrine racemic both decrease sedation. Use Caution/Monitor.
  
  albuterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• eribulin

  Monitor Closely (1)albuterol and eribulin both increase QTc interval. Use Caution/Monitor.

• erythromycin base

  Monitor Closely (1)albuterol and erythromycin base both increase QTc interval. Use Caution/Monitor.

• erythromycin ethylsuccinate

  Monitor Closely (1)albuterol and erythromycin ethylsuccinate both increase QTc interval. Use Caution/Monitor.

• erythromycin lactobionate

  Monitor Closely (1)albuterol and erythromycin lactobionate both increase QTc interval. Use Caution/Monitor.

• erythromycin stearate

  Monitor Closely (1)albuterol and erythromycin stearate both increase QTc interval. Use Caution/Monitor.

• escitalopram

  Monitor Closely (1)albuterol and escitalopram both increase QTc interval. Use Caution/Monitor.

• esmolol

  Monitor Closely (2)esmolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  esmolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• estazolam

  Monitor Closely (1)estazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ethacrynic acid

  Monitor Closely (1)albuterol and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• ethanol

  Monitor Closely (1)ethanol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• etodolac

  Monitor Closely (1)etodolac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• eucalyptus

  Minor (1)eucalyptus increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

• fenfluramine

  Monitor Closely (2)albuterol and fenfluramine both decrease sedation. Use Caution/Monitor.
  
  albuterol and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• fenoprofen

  Monitor Closely (1)fenoprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• fesoterodine

  Monitor Closely (1)fesoterodine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• fexinidazole

  Monitor Closely (1)albuterol and fexinidazole both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)fexinidazole and albuterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.

• fingolimod

  Monitor Closely (1)fingolimod and albuterol both increase QTc interval. Use Caution/Monitor.

• flavoxate

  Monitor Closely (1)flavoxate and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• flecainide

  Monitor Closely (1)albuterol and flecainide both increase QTc interval. Use Caution/Monitor.

• fluconazole

  Monitor Closely (1)albuterol and fluconazole both increase QTc interval. Use Caution/Monitor.

• fluoxetine

  Monitor Closely (1)albuterol and fluoxetine both increase QTc interval. Use Caution/Monitor.

• fluphenazine

  Monitor Closely (5)albuterol and fluphenazine both increase QTc interval. Use Caution/Monitor.
  
  fluphenazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  fluphenazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

• flurazepam

  Monitor Closely (1)flurazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• flurbiprofen

  Monitor Closely (1)flurbiprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• formoterol

  Monitor Closely (3)albuterol and formoterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and formoterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• foscarnet

  Monitor Closely (1)albuterol and foscarnet both increase QTc interval. Use Caution/Monitor.

• fostemsavir

  Monitor Closely (1)albuterol and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.

• furosemide

  Monitor Closely (1)albuterol and furosemide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• galantamine

  Monitor Closely (1)galantamine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)galantamine decreases effects of ipratropium by pharmacodynamic antagonism. Minor/Significance Unknown.

• gemifloxacin

  Monitor Closely (1)albuterol and gemifloxacin both increase QTc interval. Use Caution/Monitor.

• gemtuzumab

  Monitor Closely (1)albuterol and gemtuzumab both increase QTc interval. Use Caution/Monitor.

• gentamicin

  Monitor Closely (1)albuterol and gentamicin both decrease serum potassium. Use Caution/Monitor.

• gilteritinib

  Monitor Closely (1)albuterol and gilteritinib both increase QTc interval. Use Caution/Monitor.

• glasdegib

  Monitor Closely (1)albuterol and glasdegib both increase QTc interval. Use Caution/Monitor.

• glucagon

  Serious - Use Alternative (1)glucagon increases toxicity of ipratropium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .

• glucagon intranasal

  Serious - Use Alternative (1)glucagon intranasal increases toxicity of ipratropium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .

• glycopyrrolate

  Monitor Closely (1)glycopyrrolate and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• glycopyrrolate inhaled

  Monitor Closely (1)glycopyrrolate inhaled and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• glycopyrronium tosylate topical

  Monitor Closely (1)glycopyrronium tosylate topical, ipratropium. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.

• goserelin

  Monitor Closely (1)albuterol and goserelin both increase QTc interval. Use Caution/Monitor.

• granisetron

  Monitor Closely (1)albuterol and granisetron both increase QTc interval. Use Caution/Monitor.

• green tea

  Monitor Closely (1)green tea increases effects of albuterol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

• haloperidol

  Monitor Closely (5)albuterol and haloperidol both increase QTc interval. Use Caution/Monitor.
  
  ipratropium decreases levels of haloperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  haloperidol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of haloperidol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  haloperidol increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• henbane

  Monitor Closely (1)henbane and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• histrelin

  Monitor Closely (1)albuterol and histrelin both increase QTc interval. Use Caution/Monitor.

• homatropine

  Monitor Closely (1)homatropine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• huperzine A

  Monitor Closely (1)huperzine A increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• hydrochlorothiazide

  Monitor Closely (1)albuterol and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• hydromorphone

  Monitor Closely (1)hydromorphone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• hydroxychloroquine sulfate

  Serious - Use Alternative (1)albuterol and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.

• hydroxyzine

  Monitor Closely (2)hydroxyzine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• hyoscyamine

  Monitor Closely (1)hyoscyamine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• hyoscyamine spray

  Monitor Closely (1)hyoscyamine spray and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• ibuprofen

  Monitor Closely (1)ibuprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ibuprofen IV

  Monitor Closely (1)ibuprofen IV increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ibutilide

  Monitor Closely (1)albuterol and ibutilide both increase QTc interval. Use Caution/Monitor.

• iloperidone

  Monitor Closely (5)iloperidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of iloperidone by pharmacodynamic antagonism. Use Caution/Monitor.
  
  ipratropium decreases levels of iloperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  iloperidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  albuterol and iloperidone both increase QTc interval. Use Caution/Monitor.

• imipramine

  Monitor Closely (2)ipratropium and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  imipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• indapamide

  Monitor Closely (1)albuterol and indapamide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• indomethacin

  Monitor Closely (1)indomethacin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• inotuzumab

  Monitor Closely (1)albuterol and inotuzumab both increase QTc interval. Use Caution/Monitor.

• irbesartan

  Monitor Closely (1)irbesartan increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• isocarboxazid

  Serious - Use Alternative (1)isocarboxazid increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

• isoflurane

  Monitor Closely (1)albuterol and isoflurane both increase QTc interval. Use Caution/Monitor.

• isoproterenol

  Monitor Closely (3)albuterol and isoproterenol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and isoproterenol both decrease sedation. Use Caution/Monitor.
  
  albuterol and isoproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• itraconazole

  Monitor Closely (1)albuterol and itraconazole both increase QTc interval. Use Caution/Monitor.

• ivosidenib

  Monitor Closely (1)albuterol and ivosidenib both increase QTc interval. Use Caution/Monitor.

• ketoprofen

  Monitor Closely (1)ketoprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ketorolac

  Monitor Closely (1)ketorolac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ketorolac intranasal

  Monitor Closely (1)ketorolac intranasal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

• ketotifen, ophthalmic

  Monitor Closely (1)ketotifen, ophthalmic increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• labetalol

  Monitor Closely (2)labetalol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  labetalol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lapatinib

  Monitor Closely (1)albuterol and lapatinib both increase QTc interval. Use Caution/Monitor.

• lefamulin

  Monitor Closely (1)albuterol and lefamulin both increase QTc interval. Use Caution/Monitor.

• lenvatinib

  Monitor Closely (1)albuterol and lenvatinib both increase QTc interval. Use Caution/Monitor.

• leuprolide

  Monitor Closely (1)albuterol and leuprolide both increase QTc interval. Use Caution/Monitor.

• levalbuterol

  Monitor Closely (3)albuterol and levalbuterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and levalbuterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and levalbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• levodopa

  Minor (1)ipratropium, levodopa. Other (see comment). Minor/Significance Unknown. Comment: Anticholinergic agents may enhance the therapeutic effects of levodopa; however, anticholinergic agents can exacerbate tardive dyskinesia. In high dosage, anticholinergics may decrease the effects of levodopa by delaying its GI absorption. .

• levofloxacin

  Monitor Closely (1)albuterol and levofloxacin both increase QTc interval. Use Caution/Monitor.

• levorphanol

  Monitor Closely (1)levorphanol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• linezolid

  Serious - Use Alternative (1)linezolid increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

• lisdexamfetamine

  Monitor Closely (2)albuterol and lisdexamfetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• lithium

  Monitor Closely (1)albuterol and lithium both increase QTc interval. Use Caution/Monitor.

• lofepramine

  Monitor Closely (2)ipratropium and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor.
  
  lofepramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)lofepramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• lofexidine

  Monitor Closely (2)albuterol and lofexidine both increase QTc interval. Use Caution/Monitor.
  
  lofexidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• loperamide

  Monitor Closely (1)albuterol and loperamide both increase QTc interval. Use Caution/Monitor.

• lopinavir

  Serious - Use Alternative (1)albuterol and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.

• loprazolam

  Monitor Closely (1)loprazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lorazepam

  Monitor Closely (1)lorazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lormetazepam

  Monitor Closely (1)lormetazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lornoxicam

  Monitor Closely (1)lornoxicam increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• loxapine

  Monitor Closely (4)loxapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of loxapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  loxapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of loxapine by pharmacodynamic antagonism. Use Caution/Monitor.

• loxapine inhaled

  Monitor Closely (3)loxapine inhaled increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  loxapine inhaled increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of loxapine inhaled by pharmacodynamic antagonism. Use Caution/Monitor.

• macimorelin

  Serious - Use Alternative (1)ipratropium, macimorelin. unspecified interaction mechanism. Avoid or Use Alternate Drug. Drugs that may blunt the growth hormone (GH) response to macrimorelin may impact the accuracy of the diagnostic test. Allow sufficient washout time of drugs affecting GH release before administering macimorelin.

• maprotiline

  Monitor Closely (3)albuterol and maprotiline both increase QTc interval. Use Caution/Monitor.
  
  ipratropium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  maprotiline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)maprotiline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• marijuana

  Monitor Closely (1)marijuana increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• meclizine

  Monitor Closely (1)ipratropium and meclizine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• meclofenamate

  Monitor Closely (1)meclofenamate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• mefenamic acid

  Monitor Closely (1)mefenamic acid increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• mefloquine

  Monitor Closely (1)albuterol and mefloquine both increase QTc interval. Use Caution/Monitor.

• melatonin

  Monitor Closely (1)melatonin increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• meloxicam

  Monitor Closely (1)meloxicam increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• meperidine

  Monitor Closely (1)meperidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• meprobamate

  Monitor Closely (1)meprobamate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• metaproterenol

  Monitor Closely (3)albuterol and metaproterenol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and metaproterenol both decrease sedation. Use Caution/Monitor.
  
  albuterol and metaproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• methadone

  Monitor Closely (2)methadone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and methadone both increase QTc interval. Use Caution/Monitor.

• methamphetamine

  Monitor Closely (2)albuterol and methamphetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• methscopolamine

  Monitor Closely (1)ipratropium and methscopolamine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• methyclothiazide

  Monitor Closely (1)albuterol and methyclothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, methyclothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• methylenedioxymethamphetamine

  Monitor Closely (2)albuterol and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.
  
  albuterol and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• methylphenidate

  Monitor Closely (1)albuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• metolazone

  Monitor Closely (1)albuterol and metolazone both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, metolazone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• metoprolol

  Monitor Closely (2)metoprolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  metoprolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• midazolam

  Monitor Closely (1)midazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• midodrine

  Monitor Closely (2)albuterol and midodrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• mifepristone

  Monitor Closely (1)albuterol and mifepristone both increase QTc interval. Use Caution/Monitor.

• mirtazapine

  Monitor Closely (2)albuterol and mirtazapine both increase QTc interval. Use Caution/Monitor.
  
  mirtazapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• modafinil

  Monitor Closely (1)albuterol and modafinil both decrease sedation. Use Caution/Monitor.

• morphine

  Monitor Closely (1)morphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• motherwort

  Monitor Closely (1)motherwort increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• moxifloxacin

  Monitor Closely (1)albuterol and moxifloxacin both increase QTc interval. Use Caution/Monitor.

• moxonidine

  Monitor Closely (1)moxonidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nabilone

  Monitor Closely (1)nabilone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nabumetone

  Monitor Closely (1)nabumetone increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nadolol

  Monitor Closely (2)nadolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  nadolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nalbuphine

  Monitor Closely (1)nalbuphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• naproxen

  Monitor Closely (1)naproxen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nebivolol

  Monitor Closely (2)nebivolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  nebivolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• neostigmine

  Monitor Closely (1)neostigmine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nilotinib

  Monitor Closely (1)albuterol and nilotinib both increase QTc interval. Use Caution/Monitor.

• noni juice

  Minor (1)noni juice increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

• norepinephrine

  Monitor Closely (3)albuterol and norepinephrine both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and norepinephrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and norepinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• nortriptyline

  Monitor Closely (3)albuterol and nortriptyline both increase QTc interval. Use Caution/Monitor.
  
  nortriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.Serious - Use Alternative (1)nortriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• octreotide

  Monitor Closely (1)albuterol and octreotide both increase QTc interval. Use Caution/Monitor.

• ofloxacin

  Monitor Closely (1)albuterol and ofloxacin both increase QTc interval. Use Caution/Monitor.

• olanzapine

  Monitor Closely (5)ipratropium decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  olanzapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  olanzapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  albuterol and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances

• olodaterol inhaled

  Monitor Closely (2)albuterol and olodaterol inhaled both increase QTc interval. Use Caution/Monitor.
  
  albuterol and olodaterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effects

• onabotulinumtoxinA

  Monitor Closely (1)onabotulinumtoxinA and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• ondansetron

  Monitor Closely (1)albuterol and ondansetron both increase QTc interval. Use Caution/Monitor.

• opium tincture

  Monitor Closely (1)opium tincture increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• orphenadrine

  Monitor Closely (1)ipratropium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.

• osilodrostat

  Monitor Closely (2)osilodrostat and albuterol both increase QTc interval. Use Caution/Monitor.
  
  albuterol and osilodrostat both increase QTc interval. Use Caution/Monitor. Dose dependent QT prolongation - avoid drugs known to prolong the QT interval

• osimertinib

  Monitor Closely (1)albuterol and osimertinib both increase QTc interval. Use Caution/Monitor.

• oxaliplatin

  Monitor Closely (2)oxaliplatin will increase the level or effect of albuterol by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.
  
  albuterol and oxaliplatin both increase QTc interval. Use Caution/Monitor.

• oxaprozin

  Monitor Closely (1)oxaprozin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• oxazepam

  Monitor Closely (1)oxazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• oxybutynin

  Monitor Closely (1)ipratropium and oxybutynin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• oxybutynin topical

  Monitor Closely (1)ipratropium and oxybutynin topical both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• oxybutynin transdermal

  Monitor Closely (1)ipratropium and oxybutynin transdermal both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• oxycodone

  Monitor Closely (1)oxycodone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• oxymorphone

  Monitor Closely (1)oxymorphone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ozanimod

  Monitor Closely (1)albuterol and ozanimod both increase QTc interval. Use Caution/Monitor.

• paliperidone

  Monitor Closely (5)albuterol and paliperidone both increase QTc interval. Use Caution/Monitor.
  
  paliperidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  paliperidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of paliperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor.

• pancuronium

  Monitor Closely (1)ipratropium and pancuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• panobinostat

  Monitor Closely (1)albuterol and panobinostat both increase QTc interval. Use Caution/Monitor.

• papaveretum

  Monitor Closely (1)papaveretum increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• papaverine

  Monitor Closely (1)papaverine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• parecoxib

  Monitor Closely (1)parecoxib increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pasireotide

  Monitor Closely (1)albuterol and pasireotide both increase QTc interval. Use Caution/Monitor.

• pazopanib

  Monitor Closely (1)albuterol and pazopanib both increase QTc interval. Use Caution/Monitor.

• penbutolol

  Monitor Closely (2)penbutolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  penbutolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pentamidine

  Monitor Closely (1)albuterol and pentamidine both increase QTc interval. Use Caution/Monitor.

• pentazocine

  Monitor Closely (1)pentazocine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pentobarbital

  Monitor Closely (1)pentobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• perphenazine

  Monitor Closely (4)ipratropium decreases levels of perphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  perphenazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of perphenazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  perphenazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• phendimetrazine

  Monitor Closely (2)albuterol and phendimetrazine both decrease sedation. Use Caution/Monitor.
  
  albuterol and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• phenelzine

  Serious - Use Alternative (1)phenelzine increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

• phenobarbital

  Monitor Closely (1)phenobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• phenoxybenzamine

  Monitor Closely (1)phenoxybenzamine, albuterol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Hypotension, tachycardia.

• phentermine

  Monitor Closely (2)albuterol and phentermine both decrease sedation. Use Caution/Monitor.
  
  albuterol and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• phenylephrine

  Monitor Closely (2)albuterol and phenylephrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• phenylephrine PO

  Monitor Closely (2)albuterol and phenylephrine PO both decrease sedation. Use Caution/Monitor.
  
  albuterol and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• pholcodine

  Monitor Closely (1)pholcodine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• physostigmine

  Monitor Closely (1)physostigmine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pilocarpine

  Monitor Closely (1)pilocarpine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pimavanserin

  Monitor Closely (1)albuterol and pimavanserin both increase QTc interval. Use Caution/Monitor.

• pimozide

  Monitor Closely (4)pimozide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.
  
  ipratropium decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  pimozide increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.Serious - Use Alternative (1)albuterol and pimozide both increase QTc interval. Contraindicated.

• pindolol

  Monitor Closely (2)pindolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  pindolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pirbuterol

  Monitor Closely (3)albuterol and pirbuterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and pirbuterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• piroxicam

  Monitor Closely (1)piroxicam increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• pitolisant

  Monitor Closely (1)albuterol and pitolisant both increase QTc interval. Use Caution/Monitor.

• ponesimod

  Monitor Closely (1)albuterol and ponesimod both increase QTc interval. Use Caution/Monitor.

• posaconazole

  Monitor Closely (1)albuterol and posaconazole both increase QTc interval. Use Caution/Monitor.

• potassium acid phosphate

  Monitor Closely (1)potassium acid phosphate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• potassium chloride

  Monitor Closely (1)potassium chloride increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• pralidoxime

  Monitor Closely (1)ipratropium and pralidoxime both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• pramlintide

  Serious - Use Alternative (1)pramlintide, ipratropium. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.

• primaquine

  Monitor Closely (1)albuterol and primaquine both increase QTc interval. Use Caution/Monitor.

• primidone

  Monitor Closely (1)primidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• procainamide

  Monitor Closely (1)albuterol and procainamide both increase QTc interval. Use Caution/Monitor.

• procarbazine

  Monitor Closely (1)procarbazine increases effects of albuterol by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

• prochlorperazine

  Monitor Closely (4)prochlorperazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  prochlorperazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

• promethazine

  Monitor Closely (4)ipratropium decreases levels of promethazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  promethazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  promethazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• propafenone

  Monitor Closely (1)albuterol and propafenone both increase QTc interval. Use Caution/Monitor.

• propantheline

  Monitor Closely (1)ipratropium and propantheline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• propranolol

  Monitor Closely (2)propranolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  propranolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• propylhexedrine

  Monitor Closely (2)albuterol and propylhexedrine both decrease sedation. Use Caution/Monitor.
  
  albuterol and propylhexedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• protriptyline

  Monitor Closely (3)albuterol and protriptyline both increase QTc interval. Use Caution/Monitor.
  
  protriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (1)protriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• pseudoephedrine

  Monitor Closely (1)albuterol and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• pyridostigmine

  Monitor Closely (1)pyridostigmine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• quazepam

  Monitor Closely (1)quazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• quetiapine

  Monitor Closely (5)ipratropium decreases levels of quetiapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  quetiapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  albuterol and quetiapine both increase QTc interval. Use Caution/Monitor.
  
  quetiapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of quetiapine by pharmacodynamic antagonism. Use Caution/Monitor.

• quinidine

  Monitor Closely (1)albuterol and quinidine both increase QTc interval. Use Caution/Monitor.

• quinine

  Monitor Closely (1)albuterol and quinine both increase QTc interval. Use Caution/Monitor.

• ranolazine

  Monitor Closely (1)albuterol and ranolazine both increase QTc interval. Use Caution/Monitor.

• rapacuronium

  Monitor Closely (1)ipratropium and rapacuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• revefenacin

  Serious - Use Alternative (1)revefenacin and ipratropium both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Coadministration may cause additive anticholinergic effects.

• ribociclib

  Monitor Closely (1)albuterol and ribociclib both increase QTc interval. Use Caution/Monitor.

• rilpivirine

  Monitor Closely (1)albuterol and rilpivirine both increase QTc interval. Use Caution/Monitor.

• risperidone

  Monitor Closely (3)albuterol and risperidone both increase QTc interval. Use Caution/Monitor.
  
  risperidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  risperidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• rocuronium

  Monitor Closely (1)ipratropium and rocuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

• romidepsin

  Monitor Closely (1)albuterol and romidepsin both increase QTc interval. Use Caution/Monitor.

• sacubitril/valsartan

  Monitor Closely (1)sacubitril/valsartan increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sage

  Minor (1)sage increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

• salicylates (non-asa)

  Monitor Closely (1)salicylates (non-asa) increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• salmeterol

  Monitor Closely (3)albuterol and salmeterol both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and salmeterol both decrease sedation. Use Caution/Monitor.
  
  albuterol and salmeterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• salsalate

  Monitor Closely (1)salsalate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• saquinavir

  Contraindicated (1)saquinavir, albuterol. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated. Contraindicated. Saquinavir boosted with ritonavir increases risk of hypokalemia, QT prolongation, and cardiac arrhythmias.Monitor Closely (1)albuterol and saquinavir both increase QTc interval. Use Caution/Monitor.

• scopolamine

  Monitor Closely (1)ipratropium and scopolamine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• scullcap

  Monitor Closely (1)scullcap increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• secobarbital

  Monitor Closely (1)secobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• selpercatinib

  Monitor Closely (1)albuterol and selpercatinib both increase QTc interval. Use Caution/Monitor.

• serdexmethylphenidate/dexmethylphenidate

  Monitor Closely (1)albuterol and serdexmethylphenidate/dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• sertraline

  Monitor Closely (1)albuterol and sertraline both increase QTc interval. Use Caution/Monitor.

• sevoflurane

  Monitor Closely (1)albuterol and sevoflurane both increase QTc interval. Use Caution/Monitor.

• shepherd's purse

  Monitor Closely (1)shepherd's purse increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• siponimod

  Monitor Closely (1)albuterol and siponimod both increase QTc interval. Use Caution/Monitor.

• sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol

  Monitor Closely (1)albuterol and sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol both decrease serum potassium. Modify Therapy/Monitor Closely.

• solifenacin

  Monitor Closely (2)ipratropium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
  
  albuterol and solifenacin both increase QTc interval. Use Caution/Monitor.

• solriamfetol

  Monitor Closely (1)albuterol and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• sorafenib

  Monitor Closely (1)albuterol and sorafenib both increase QTc interval. Use Caution/Monitor.

• sotalol

  Monitor Closely (3)sotalol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  albuterol and sotalol both increase QTc interval. Use Caution/Monitor.
  
  sotalol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• spironolactone

  Monitor Closely (1)spironolactone increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• succinylcholine

  Monitor Closely (2)succinylcholine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  succinylcholine increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sufentanil

  Monitor Closely (1)sufentanil increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sulfasalazine

  Monitor Closely (1)sulfasalazine increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sulindac

  Monitor Closely (1)sulindac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• sunitinib

  Monitor Closely (1)albuterol and sunitinib both increase QTc interval. Use Caution/Monitor.

• tacrolimus

  Monitor Closely (1)albuterol and tacrolimus both increase QTc interval. Use Caution/Monitor.

• tapentadol

  Monitor Closely (1)tapentadol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• telavancin

  Monitor Closely (1)albuterol and telavancin both increase QTc interval. Use Caution/Monitor.

• temazepam

  Monitor Closely (1)temazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• terbutaline

  Monitor Closely (3)albuterol and terbutaline both decrease serum potassium. Use Caution/Monitor.
  
  albuterol and terbutaline both decrease sedation. Use Caution/Monitor.
  
  albuterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• tetrabenazine

  Monitor Closely (1)albuterol and tetrabenazine both increase QTc interval. Use Caution/Monitor.

• thioridazine

  Contraindicated (1)albuterol and thioridazine both increase QTc interval. Contraindicated.Monitor Closely (4)thioridazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  thioridazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of thioridazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of thioridazine by pharmacodynamic antagonism. Use Caution/Monitor.

• thiothixene

  Monitor Closely (4)thiothixene increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  ipratropium decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor.
  
  thiothixene increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

• timolol

  Monitor Closely (2)timolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.
  
  timolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• tiotropium

  Monitor Closely (1)ipratropium and tiotropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• tolfenamic acid

  Monitor Closely (1)tolfenamic acid increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• tolmetin

  Monitor Closely (1)tolmetin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• tolterodine

  Monitor Closely (1)ipratropium and tolterodine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• tolvaptan

  Monitor Closely (1)tolvaptan increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• topiramate

  Monitor Closely (1)topiramate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• toremifene

  Monitor Closely (1)albuterol and toremifene both increase QTc interval. Use Caution/Monitor.

• torsemide

  Monitor Closely (1)albuterol and torsemide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, torsemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

• tramadol

  Monitor Closely (1)tramadol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• tranylcypromine

  Serious - Use Alternative (1)tranylcypromine increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

• trazodone

  Monitor Closely (3)trazodone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  albuterol and trazodone both increase QTc interval. Use Caution/Monitor.
  
  ipratropium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (1)trazodone, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• triamterene

  Monitor Closely (1)triamterene increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

• triazolam

  Monitor Closely (1)triazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• triclabendazole

  Monitor Closely (1)albuterol and triclabendazole both increase QTc interval. Use Caution/Monitor.

• triclofos

  Monitor Closely (1)triclofos increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• trifluoperazine

  Monitor Closely (4)ipratropium decreases levels of trifluoperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of trifluoperazine by pharmacodynamic antagonism. Use Caution/Monitor.
  
  trifluoperazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  trifluoperazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

• trihexyphenidyl

  Monitor Closely (1)ipratropium and trihexyphenidyl both decrease cholinergic effects/transmission. Use Caution/Monitor. Potential for additive anticholinergic effects.

• trimipramine

  Monitor Closely (3)albuterol and trimipramine both increase QTc interval. Use Caution/Monitor.
  
  trimipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ipratropium and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.Serious - Use Alternative (1)trimipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

• triprolidine

  Monitor Closely (1)triprolidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• triptorelin

  Monitor Closely (1)albuterol and triptorelin both increase QTc interval. Use Caution/Monitor.

• trospium chloride

  Monitor Closely (1)ipratropium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• umeclidinium bromide

  Monitor Closely (1)umeclidinium bromide and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. If possible, avoid coadministration of additional anticholinergic agents

• umeclidinium bromide/vilanterol inhaled

  Serious - Use Alternative (1)ipratropium, umeclidinium bromide/vilanterol inhaled. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Concomitant use with other anticholinergic-containing drugs may lead to additive anticholinergic adverse effects.

• vandetanib

  Monitor Closely (1)albuterol and vandetanib both increase QTc interval. Use Caution/Monitor.

• vardenafil

  Monitor Closely (1)albuterol and vardenafil both increase QTc interval. Use Caution/Monitor.

• vecuronium

  Monitor Closely (1)ipratropium and vecuronium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

• vemurafenib

  Monitor Closely (1)albuterol and vemurafenib both increase QTc interval. Use Caution/Monitor.

• voclosporin

  Monitor Closely (1)albuterol and voclosporin both increase QTc interval. Use Caution/Monitor.

• voriconazole

  Monitor Closely (1)albuterol and voriconazole both increase QTc interval. Use Caution/Monitor.

• vorinostat

  Monitor Closely (1)albuterol and vorinostat both increase QTc interval. Use Caution/Monitor.

• xylometazoline

  Monitor Closely (2)albuterol and xylometazoline both decrease sedation. Use Caution/Monitor.
  
  albuterol and xylometazoline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• yohimbine

  Monitor Closely (2)albuterol and yohimbine both decrease sedation. Use Caution/Monitor.
  
  albuterol and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

• ziconotide

  Monitor Closely (1)ziconotide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ziprasidone

  Monitor Closely (5)ziprasidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  
  ziprasidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
  
  albuterol and ziprasidone both increase QTc interval. Use Caution/Monitor.
  
  ipratropium decreases levels of ziprasidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of ziprasidone by pharmacodynamic antagonism. Use Caution/Monitor.

• zotepine

  Monitor Closely (2)ipratropium decreases levels of zotepine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
  
  ipratropium decreases levels of zotepine by pharmacodynamic antagonism. Use Caution/Monitor.