urea/hydrocortisone topical (Rx)

Brand and Other Names:Carmol HC, U-Cort
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

urea/hydrocortisone topical

topical cream

  • 10%/1%

Dermatoses

Relief of inflammation and pruritic associated with corticosteroid-responsive dermatoses

Apply to affected area q6-12hr; discontinue therapy when control achieved

If no improvement within 2 weeks, reassess diagnosis

Dosage Forms & Strengths

Urea/hydrocortisone topical

topical cream

  • 10%/1%

Dermatoses

Apply to affected area q6-12hr; discontinue therapy when control achieved

If no improvement within 2 weeks, reassess diagnosis

Limit use in children to least amount compatible with an effective therapeutic regimen

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Interactions

Interaction Checker

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                    Adverse Effects

                    Frequency Not Defined

                    Burning

                    Itching

                    Irritation

                    Dryness

                    Folliculitis

                    Hypertrichosis

                    Acneiform eruptions

                    Hypopigmentation

                    Perioral dermatitis

                    Allergic contact dermatitis

                    Maceration of the skin

                    Secondary infection

                    Skin atrophy

                    Striae

                    Miliaria

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                    Warnings

                    Contraindications

                    Hypersensitivity to any components of preparation

                    Hepatic insufficiency

                    Cautions

                    Prolonged use may result in fungal or bacterial infection

                    Contains sodium metabisulfite, which may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people

                    Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glucosuria

                    Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use and the addition of occlusive dressings Evaluate susceptible patients periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests; If HPA axis suppression is noted, withdraw the drug, reduce frequency of application, or substitute less potent steroid

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                    Pregnancy & Lactation

                    Pregnancy Category: C

                    Lactation: Systemic hydrocortisone is excreted in breast milk, use caution

                    Pregnancy Categories

                    A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                    B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                    C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                    D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                    X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                    NA: Information not available.

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                    Pharmacology

                    Mechanism of Action

                    Hydrocortisone: anti-inflammatory, antipruritic and vasoconstrictive actions; mechanism of anti-inflammatory activity of topical corticosteroids unclear

                    Absorption

                    Extent determined by many factors including vehicle, integrity of epidermal barrier, use of occlusive dressings

                    Protein Bound

                    Variable

                    Metabolism

                    Primarily by liver

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                    Images

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                    Patient Handout

                    A Patient Handout is not currently available for this monograph.
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                    Formulary

                    FormularyPatient Discounts

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                    The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                    Tier Description
                    1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                    2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                    3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                    4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                    5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                    6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                    NC NOT COVERED – Drugs that are not covered by the plan.
                    Code Definition
                    PA Prior Authorization
                    Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                    QL Quantity Limits
                    Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                    ST Step Therapy
                    Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                    OR Other Restrictions
                    Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                    Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.