urea/hydrocortisone topical (Rx)

Brand and Other Names:Carmol HC, U-Cort
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

urea/hydrocortisone topical

topical cream

  • 10%/1%

Dermatoses

Relief of inflammation and pruritic associated with corticosteroid-responsive dermatoses

Apply to affected area q6-12hr; discontinue therapy when control achieved

If no improvement within 2 weeks, reassess diagnosis

Dosage Forms & Strengths

Urea/hydrocortisone topical

topical cream

  • 10%/1%

Dermatoses

Apply to affected area q6-12hr; discontinue therapy when control achieved

If no improvement within 2 weeks, reassess diagnosis

Limit use in children to least amount compatible with an effective therapeutic regimen

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Interactions

Interaction Checker

and urea/hydrocortisone topical

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (4)

                • atogepant

                  hydrocortisone topical will decrease the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • axitinib

                  hydrocortisone topical decreases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • collagenase

                  urea decreases effects of collagenase by increasing metabolism. Use Caution/Monitor.

                • isavuconazonium sulfate

                  hydrocortisone topical will decrease the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                Minor (1)

                • vasopressin

                  urea increases effects of vasopressin by pharmacodynamic synergism. Minor/Significance Unknown.

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                Adverse Effects

                Frequency Not Defined

                Burning

                Itching

                Irritation

                Dryness

                Folliculitis

                Hypertrichosis

                Acneiform eruptions

                Hypopigmentation

                Perioral dermatitis

                Allergic contact dermatitis

                Maceration of the skin

                Secondary infection

                Skin atrophy

                Striae

                Miliaria

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                Warnings

                Contraindications

                Hypersensitivity to any components of preparation

                Hepatic insufficiency

                Cautions

                Prolonged use may result in fungal or bacterial infection

                Contains sodium metabisulfite, which may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people

                Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glucosuria

                Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use and the addition of occlusive dressings Evaluate susceptible patients periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests; If HPA axis suppression is noted, withdraw the drug, reduce frequency of application, or substitute less potent steroid

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                Pregnancy & Lactation

                Pregnancy Category: C

                Lactation: Systemic hydrocortisone is excreted in breast milk, use caution

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Hydrocortisone: anti-inflammatory, antipruritic and vasoconstrictive actions; mechanism of anti-inflammatory activity of topical corticosteroids unclear

                Absorption

                Extent determined by many factors including vehicle, integrity of epidermal barrier, use of occlusive dressings

                Protein Bound

                Variable

                Metabolism

                Primarily by liver

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                Images

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                Patient Handout

                A Patient Handout is not currently available for this monograph.
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                Formulary

                FormularyPatient Discounts

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                The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                Tier Description
                1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                NC NOT COVERED – Drugs that are not covered by the plan.
                Code Definition
                PA Prior Authorization
                Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                QL Quantity Limits
                Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
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                Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.