terbutaline (Rx)

Brand and Other Names:Brethaire, Brethine, more...Bricanyl
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 2.5mg
  • 5mg

injectable solution

  • 1mg/mL

Bronchospasm

PO

  • Initiate at 2.5 mg three/four times daily PO
  • Maintenance: 5 mg three times daily PO q6hr while patient is awake; reduce dose to 2.5 mg q6hr
  • Not to exceed 15 mg/Day

SC

  • 0.25 mg q15-30min x 3 doses PRN in lateral deltoid
  • Not to exceed 0.5 mg/4 hr

Preterm Labor (Off-label)

Initiate at 2.5-5 mcg/min IV

Increase gradually as tolerated at 20-30 minute intervals

Typical effective dose ranges between 17.5-30 mcg/min IV; some require doses up to 70-80 mcg/min

Continue infusion for 12 hr following cessation of uterine contractions; not to exceed 48-72 hr

PO use or prolonged IV use not recommended (see Black Box Warnings)

Renal Impairment

GFR <50 mL/min: reduce dose by 50%

GFR >50mL/min: Dose adjustment not necessary

Dosage Forms & Strengths

tablet

  • 2.5mg
  • 5mg

injectable solution

  • 1mg/mL

Bronchospasm

PO

  • <12 years: 0.05 mg/kg three times daily initially; increase PRN, not to exceed 5 mg/day  
  • 12-15 years: 2.5 mg PO q6hr 3 times daily; not to exceed 7.5 mg/day
  • >15 years: 5 mg/dose PO q8hr three times daily; reduce dose to 2.5 mg q6hr; not to exceed 15 mg/24hr

SC (in lateral deltoid)

  • <12 years: 0.005-0.01 mg/kg (no more than 0.4 mg) q15-20min x 3; THEN q2-6hour PRN  
  • >12 years: 0.25 mg q15-30min x 3 doses PRN in lateral deltoid; not to exceed 0.5 mg/4 hr
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Interactions

Interaction Checker

and terbutaline

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              Serious - Use Alternative (18)

              • amitriptyline

                amitriptyline, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • amoxapine

                amoxapine, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • clomipramine

                clomipramine, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • desipramine

                desipramine, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • doxepin

                doxepin, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • fexinidazole

                fexinidazole and terbutaline both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.

              • imipramine

                imipramine, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • isocarboxazid

                isocarboxazid increases effects of terbutaline by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

              • lefamulin

                lefamulin and terbutaline both increase QTc interval. Avoid or Use Alternate Drug.

              • linezolid

                linezolid increases effects of terbutaline by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

              • lofepramine

                lofepramine, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • maprotiline

                maprotiline, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • nortriptyline

                nortriptyline, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • phenelzine

                phenelzine increases effects of terbutaline by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

              • protriptyline

                protriptyline, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • tranylcypromine

                tranylcypromine increases effects of terbutaline by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

              • trazodone

                trazodone, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              • trimipramine

                trimipramine, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

              Monitor Closely (239)

              • acebutolol

                acebutolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                acebutolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • aceclofenac

                aceclofenac increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • acemetacin

                acemetacin increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • albuterol

                albuterol and terbutaline both decrease serum potassium. Use Caution/Monitor.

                albuterol and terbutaline both decrease sedation. Use Caution/Monitor.

                albuterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • alfentanil

                alfentanil increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • alprazolam

                alprazolam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • amiloride

                amiloride increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • amitriptyline

                amitriptyline increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • amobarbital

                amobarbital increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • amoxapine

                amoxapine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • arformoterol

                arformoterol and terbutaline both decrease serum potassium. Use Caution/Monitor.

                arformoterol and terbutaline both decrease sedation. Use Caution/Monitor.

                arformoterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • aripiprazole

                aripiprazole increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • armodafinil

                terbutaline and armodafinil both decrease sedation. Use Caution/Monitor.

              • aspirin

                aspirin increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • aspirin rectal

                aspirin rectal increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

              • aspirin/citric acid/sodium bicarbonate

                aspirin/citric acid/sodium bicarbonate increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • atenolol

                atenolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                atenolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • atomoxetine

                terbutaline, atomoxetine. Other (see comment). Use Caution/Monitor. Comment: Exercise caution if beta-agonists and atomoxetine are coadministered. Interaction may be less likely with inhaled beta-agonists versus those given systemically. .

              • azelastine

                azelastine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • belladonna and opium

                belladonna and opium increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • bendroflumethiazide

                terbutaline and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.

              • benperidol

                benperidol increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • benzphetamine

                terbutaline and benzphetamine both decrease sedation. Use Caution/Monitor.

                terbutaline and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • betaxolol

                betaxolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                betaxolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • bisoprolol

                bisoprolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                bisoprolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • brompheniramine

                brompheniramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • bumetanide

                terbutaline and bumetanide both decrease serum potassium. Use Caution/Monitor.

              • buprenorphine buccal

                buprenorphine buccal increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • butabarbital

                butabarbital increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • butalbital

                butalbital increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • butorphanol

                butorphanol increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • caffeine

                terbutaline and caffeine both decrease sedation. Use Caution/Monitor.

              • candesartan

                candesartan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • carbenoxolone

                terbutaline and carbenoxolone both decrease serum potassium. Use Caution/Monitor.

              • carbinoxamine

                carbinoxamine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • carvedilol

                carvedilol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                carvedilol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • celecoxib

                celecoxib increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • celiprolol

                celiprolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                celiprolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • chloral hydrate

                chloral hydrate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • chlordiazepoxide

                chlordiazepoxide increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • chlorothiazide

                terbutaline and chlorothiazide both decrease serum potassium. Use Caution/Monitor.

              • chlorpheniramine

                chlorpheniramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • chlorpromazine

                chlorpromazine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • chlorthalidone

                terbutaline and chlorthalidone both decrease serum potassium. Use Caution/Monitor.

              • choline magnesium trisalicylate

                choline magnesium trisalicylate increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

              • cinnarizine

                cinnarizine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • clemastine

                clemastine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • clomipramine

                clomipramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • clonazepam

                clonazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • clorazepate

                clorazepate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • clozapine

                clozapine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • codeine

                codeine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • cyclizine

                cyclizine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • cyclopenthiazide

                terbutaline and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.

              • cyproheptadine

                cyproheptadine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • deflazacort

                terbutaline and deflazacort both decrease serum potassium. Use Caution/Monitor.

              • desipramine

                desipramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dexchlorpheniramine

                dexchlorpheniramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dexfenfluramine

                terbutaline and dexfenfluramine both decrease sedation. Use Caution/Monitor.

                terbutaline and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • dexmedetomidine

                dexmedetomidine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dexmethylphenidate

                terbutaline and dexmethylphenidate both decrease sedation. Use Caution/Monitor.

                terbutaline and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • dextroamphetamine

                terbutaline and dextroamphetamine both decrease sedation. Use Caution/Monitor.

                terbutaline and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • dextromoramide

                dextromoramide increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • diamorphine

                diamorphine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dichlorphenamide

                dichlorphenamide and terbutaline both decrease serum potassium. Use Caution/Monitor.

              • diclofenac

                diclofenac increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • diethylpropion

                terbutaline and diethylpropion both decrease sedation. Use Caution/Monitor.

                terbutaline and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • difenoxin hcl

                difenoxin hcl increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • diflunisal

                diflunisal increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • digoxin

                digoxin increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dimenhydrinate

                dimenhydrinate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • diphenhydramine

                diphenhydramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • diphenoxylate hcl

                diphenoxylate hcl increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dipipanone

                dipipanone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dobutamine

                dobutamine and terbutaline both decrease serum potassium. Use Caution/Monitor.

                dobutamine and terbutaline both decrease sedation. Use Caution/Monitor.

                dobutamine and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • dopamine

                terbutaline and dopamine both decrease sedation. Use Caution/Monitor.

                terbutaline and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • dopexamine

                dopexamine and terbutaline both decrease serum potassium. Use Caution/Monitor.

                dopexamine and terbutaline both decrease sedation. Use Caution/Monitor.

                dopexamine and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                dopexamine, terbutaline. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.

              • doxepin

                doxepin increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • droperidol

                droperidol increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • drospirenone

                drospirenone increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • ephedrine

                ephedrine and terbutaline both decrease serum potassium. Use Caution/Monitor.

                ephedrine and terbutaline both decrease sedation. Use Caution/Monitor.

                ephedrine and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • epinephrine

                epinephrine and terbutaline both decrease serum potassium. Use Caution/Monitor.

                epinephrine and terbutaline both decrease sedation. Use Caution/Monitor.

                epinephrine and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • epinephrine racemic

                epinephrine racemic and terbutaline both decrease serum potassium. Use Caution/Monitor.

                epinephrine racemic and terbutaline both decrease sedation. Use Caution/Monitor.

                epinephrine racemic and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • eprosartan

                eprosartan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • esmolol

                esmolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                esmolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • estazolam

                estazolam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ethacrynic acid

                terbutaline and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.

              • ethanol

                ethanol increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • etodolac

                etodolac increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • fenfluramine

                terbutaline and fenfluramine both decrease sedation. Use Caution/Monitor.

                terbutaline and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • fenoprofen

                fenoprofen increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • fluoxetine

                fluoxetine and terbutaline both increase QTc interval. Modify Therapy/Monitor Closely. Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of beta2 agonists on the cardiovascular system

              • fluphenazine

                fluphenazine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • flurazepam

                flurazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • flurbiprofen

                flurbiprofen increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • formoterol

                formoterol and terbutaline both decrease serum potassium. Use Caution/Monitor.

                formoterol and terbutaline both decrease sedation. Use Caution/Monitor.

                formoterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • fostemsavir

                terbutaline and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.

              • furosemide

                terbutaline and furosemide both decrease serum potassium. Use Caution/Monitor.

              • gentamicin

                terbutaline and gentamicin both decrease serum potassium. Use Caution/Monitor.

              • green tea

                green tea increases effects of terbutaline by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • haloperidol

                haloperidol increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • hydrochlorothiazide

                terbutaline and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.

              • hydromorphone

                hydromorphone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • hydroxyzine

                hydroxyzine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ibuprofen

                ibuprofen increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ibuprofen IV

                ibuprofen IV increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • iloperidone

                iloperidone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • imipramine

                imipramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • indapamide

                terbutaline and indapamide both decrease serum potassium. Use Caution/Monitor.

              • indomethacin

                indomethacin increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • irbesartan

                irbesartan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • isoproterenol

                isoproterenol and terbutaline both decrease serum potassium. Use Caution/Monitor.

                isoproterenol and terbutaline both decrease sedation. Use Caution/Monitor.

                isoproterenol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • ketoprofen

                ketoprofen increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ketorolac

                ketorolac increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ketorolac intranasal

                ketorolac intranasal increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

              • ketotifen, ophthalmic

                ketotifen, ophthalmic increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • labetalol

                labetalol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                labetalol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • levalbuterol

                levalbuterol and terbutaline both decrease serum potassium. Use Caution/Monitor.

                levalbuterol and terbutaline both decrease sedation. Use Caution/Monitor.

                levalbuterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • levorphanol

                levorphanol increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • lisdexamfetamine

                terbutaline and lisdexamfetamine both decrease sedation. Use Caution/Monitor.

                terbutaline and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • lofepramine

                lofepramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • lofexidine

                lofexidine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • loprazolam

                loprazolam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • lorazepam

                lorazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • lormetazepam

                lormetazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • lornoxicam

                lornoxicam increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • losartan

                losartan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • loxapine

                loxapine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • loxapine inhaled

                loxapine inhaled increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • maprotiline

                maprotiline increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • marijuana

                marijuana increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • meclofenamate

                meclofenamate increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • mefenamic acid

                mefenamic acid increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • melatonin

                melatonin increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • meloxicam

                meloxicam increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • meperidine

                meperidine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • meprobamate

                meprobamate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • metaproterenol

                metaproterenol and terbutaline both decrease serum potassium. Use Caution/Monitor.

                metaproterenol and terbutaline both decrease sedation. Use Caution/Monitor.

                metaproterenol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • methadone

                methadone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • methamphetamine

                terbutaline and methamphetamine both decrease sedation. Use Caution/Monitor.

                terbutaline and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • methylenedioxymethamphetamine

                terbutaline and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.

                terbutaline and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • methylphenidate

                terbutaline and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • metolazone

                terbutaline and metolazone both decrease serum potassium. Use Caution/Monitor.

              • metoprolol

                metoprolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                metoprolol increases effects of terbutaline by pharmacodynamic synergism. Use Caution/Monitor.

                metoprolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • midazolam

                midazolam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • midodrine

                terbutaline and midodrine both decrease sedation. Use Caution/Monitor.

                terbutaline and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • mirtazapine

                mirtazapine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • modafinil

                terbutaline and modafinil both decrease sedation. Use Caution/Monitor.

              • morphine

                morphine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • motherwort

                motherwort increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • moxonidine

                moxonidine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • nabilone

                nabilone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • nabumetone

                nabumetone increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • nadolol

                nadolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                nadolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • nalbuphine

                nalbuphine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • naproxen

                naproxen increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • nebivolol

                nebivolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                nebivolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • norepinephrine

                norepinephrine and terbutaline both decrease serum potassium. Use Caution/Monitor.

                norepinephrine and terbutaline both decrease sedation. Use Caution/Monitor.

                norepinephrine and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • nortriptyline

                nortriptyline increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • olanzapine

                olanzapine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • olmesartan

                olmesartan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • olodaterol inhaled

                terbutaline and olodaterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effects

              • opium tincture

                opium tincture increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • osilodrostat

                osilodrostat and terbutaline both increase QTc interval. Use Caution/Monitor.

              • oxaprozin

                oxaprozin increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • oxazepam

                oxazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • oxycodone

                oxycodone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • oxymorphone

                oxymorphone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • paliperidone

                paliperidone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • papaveretum

                papaveretum increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • parecoxib

                parecoxib increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • penbutolol

                penbutolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                penbutolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • pentazocine

                pentazocine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • pentobarbital

                pentobarbital increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • perphenazine

                perphenazine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phendimetrazine

                terbutaline and phendimetrazine both decrease sedation. Use Caution/Monitor.

                terbutaline and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • phenobarbital

                phenobarbital increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenoxybenzamine

                phenoxybenzamine, terbutaline. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Hypotension, tachycardia.

              • phentermine

                terbutaline and phentermine both decrease sedation. Use Caution/Monitor.

                terbutaline and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • phenylephrine

                terbutaline and phenylephrine both decrease sedation. Use Caution/Monitor.

                terbutaline and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • phenylephrine PO

                terbutaline and phenylephrine PO both decrease sedation. Use Caution/Monitor.

                terbutaline and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • pholcodine

                pholcodine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • pimozide

                pimozide increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • pindolol

                pindolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                pindolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • pirbuterol

                pirbuterol and terbutaline both decrease serum potassium. Use Caution/Monitor.

                pirbuterol and terbutaline both decrease sedation. Use Caution/Monitor.

                pirbuterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • piroxicam

                piroxicam increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • potassium acid phosphate

                potassium acid phosphate increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • potassium chloride

                potassium chloride increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • potassium citrate

                potassium citrate increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • primidone

                primidone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • procarbazine

                procarbazine increases effects of terbutaline by pharmacodynamic synergism. Use Caution/Monitor.

              • prochlorperazine

                prochlorperazine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • promethazine

                promethazine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • propranolol

                propranolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                propranolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • propylhexedrine

                terbutaline and propylhexedrine both decrease sedation. Use Caution/Monitor.

                terbutaline and propylhexedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • protriptyline

                protriptyline increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • pseudoephedrine

                terbutaline and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • quazepam

                quazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • quetiapine

                quetiapine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • risperidone

                risperidone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • sacubitril/valsartan

                sacubitril/valsartan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • salicylates (non-asa)

                salicylates (non-asa) increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • salmeterol

                salmeterol and terbutaline both decrease serum potassium. Use Caution/Monitor.

                salmeterol and terbutaline both decrease sedation. Use Caution/Monitor.

                salmeterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • salsalate

                salsalate increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • scullcap

                scullcap increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • secobarbital

                secobarbital increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • shepherd's purse

                shepherd's purse increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol

                terbutaline and sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol both decrease serum potassium. Modify Therapy/Monitor Closely.

              • solriamfetol

                terbutaline and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • sotalol

                sotalol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                sotalol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • spironolactone

                spironolactone increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • succinylcholine

                succinylcholine increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • sufentanil

                sufentanil increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • sulfasalazine

                sulfasalazine increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • sulindac

                sulindac increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • tapentadol

                tapentadol increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • telmisartan

                telmisartan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • temazepam

                temazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • thioridazine

                thioridazine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • thiothixene

                thiothixene increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • timolol

                timolol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                timolol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

              • tolfenamic acid

                tolfenamic acid increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • tolmetin

                tolmetin increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • tolvaptan

                tolvaptan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • topiramate

                topiramate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • torsemide

                terbutaline and torsemide both decrease serum potassium. Use Caution/Monitor.

              • tramadol

                tramadol increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • trazodone

                trazodone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • triamterene

                triamterene increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • triazolam

                triazolam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • triclofos

                triclofos increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • trifluoperazine

                trifluoperazine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • trimipramine

                trimipramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • triprolidine

                triprolidine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • valsartan

                valsartan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • xylometazoline

                terbutaline and xylometazoline both decrease sedation. Use Caution/Monitor.

                terbutaline and xylometazoline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • yohimbine

                terbutaline and yohimbine both decrease sedation. Use Caution/Monitor.

                terbutaline and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

              • ziconotide

                ziconotide increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ziprasidone

                ziprasidone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              Minor (15)

              • bendroflumethiazide

                terbutaline, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                bendroflumethiazide, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • bumetanide

                terbutaline, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                bumetanide, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • chlorothiazide

                terbutaline, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                chlorothiazide, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • chlorthalidone

                terbutaline, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                chlorthalidone, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • cyclopenthiazide

                terbutaline, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                cyclopenthiazide, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • ethacrynic acid

                terbutaline, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                ethacrynic acid, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • eucalyptus

                eucalyptus increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

              • furosemide

                terbutaline, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                furosemide, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • hydrochlorothiazide

                terbutaline, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                hydrochlorothiazide, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • indapamide

                terbutaline, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                indapamide, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • methyclothiazide

                methyclothiazide, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • metolazone

                terbutaline, metolazone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                metolazone, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

              • noni juice

                noni juice increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

              • sage

                sage increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

              • torsemide

                terbutaline, torsemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                torsemide, terbutaline. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects.

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              Adverse Effects

              Frequency Not Defined

              Nervousness

              Restlessness

              Transient hyperglycemia

              Transient hypokalemia

              Trembling

              Tachycardia

              HTN

              Pounding heartbeat

              Dizziness

              Lightheadedness

              Drowsiness

              Headache

              Insomnia

              Dry mouth

              Nausea

              Vomiting

              Bad taste in mouth

              Muscle cramps

              Weakness

              Diaphoresis

              Cardiac arrhythmias

              Pulmonary edema

              Myocardial ischemia

              Myocardial infarction

              Increased fetal heart rate

              Hypoglycemia in some neonates born to women who received drug during labor

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              Warnings

              Black Box Warnings

              Risk of serious adverse events outweighs potential benefit to pregnant women receiving prlonged treatment with terbutaline injection (ie, >48-72 hr), or acute or prolonged treatment with oral terbutaline

              Oral terbutaline should not be used for prevention or any treatment of preterm labor because efficacy has not been established and safety concerns similar to IV administration exist

              Death and serious adverse reactions have been reported following prolonged administration of oral or injectable terbutaline to pregnant women

              Serious events following prolonged use include tachycardia, transient hyperglycemia, hypokalemia, arrhythmias, pulmonary edema, and myocardial ischemia

              Contraindications

              Hypersensitivity to sympathomimetics

              Use >72 hr in management or prevention of preterm labor

              Oral administration in preterm labor

              Cautions

              Diabetes mellitus

              Hypertension

              Hyperthyroidism

              History of seizures

              History of cardiac disease, including ischemic heart disease or associated arrhythmias

              Paradoxical bronchoconstriction may occur with excessive use

              Fatalities reported with excessive use of sympathomimetics

              Optimize anti-inflammatory treatment prior to administering terbutaline for asthma therapy

              Beta-2 agonists may increase serum glucose; use caution in patients with diabetes mellitus

              Use caution in glaucoma, hyperthyroidism, seizure disorders, and hypokalemia

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              Pregnancy & Lactation

              Pregnancy Category: C

              Lactation: Distributed into breast milk, but in amounts generally considered insufficient to affect nursing infants (AAP Committee states compatible with nursing)

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              Beta adrenergic receptor stimulator causing bronchial/uterine smooth muscle relaxation

              Pharmacokinetics

              Onset: 30-45 min (PO); 6-15 min (SC)

              Duration: 90 min-4 hr

              Peak plasma time: 30-60 min

              Half-life: 11-16 hr

              Protein binding: 25%

              Absorbtion: 33-50%

              Metabolism: Partially metabolized in liver, mainly to inactive sulfate conjugate

              Excretion: 60% urine unchanged, up to 3% feces via bile; remainder in urine as the conjugate (w/ parenteral admin)

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              Administration

              IV Preparation

              Solution: dilute as required in D5W (available form: 1 mg/mL)

              Administration: use infusion pump

              Protect inj from light

              Do not use if discolored

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              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              terbutaline oral
              -
              2.5 mg tablet
              terbutaline oral
              -
              5 mg tablet
              terbutaline oral
              -
              2.5 mg tablet
              terbutaline oral
              -
              5 mg tablet
              terbutaline oral
              -
              2.5 mg tablet
              terbutaline oral
              -
              5 mg tablet
              terbutaline subcutaneous
              -
              1 mg/mL vial
              terbutaline subcutaneous
              -
              1 mg/mL vial
              terbutaline subcutaneous
              -
              1 mg/mL vial
              terbutaline subcutaneous
              -
              1 mg/mL vial
              terbutaline subcutaneous
              -
              1 mg/mL vial
              terbutaline subcutaneous
              -
              1 mg/mL vial

              Copyright © 2010 First DataBank, Inc.

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              Patient Handout

              Select a drug:
              Patient Education
              terbutaline oral

              TERBUTALINE - ORAL

              (ter-BYOO-ta-leen)

              COMMON BRAND NAME(S): Brethine

              WARNING: Terbutaline should not be used to prevent or treat early labor, since it has risks to the mother that are greater than the benefits. Serious (sometimes fatal) side effects have rarely occurred in mothers taking terbutaline during labor, such as chest pain, fast/irregular heartbeats, and trouble breathing. If you are pregnant or become pregnant and are taking terbutaline for another medical condition (such as asthma), talk to your doctor or pharmacist about whether terbutaline is still right for you.

              USES: Terbutaline is used to treat wheezing and shortness of breath from lung problems (e.g., asthma, chronic obstructive pulmonary disease, bronchitis and emphysema). Controlling these symptoms can decrease time lost from work or school. Terbutaline belongs to a class of drugs known as bronchodilators. It works by relaxing the muscles around the airways so that they open up and you can breathe more easily.

              HOW TO USE: Take this medication by mouth with or without food, usually 3 times daily or as directed by your doctor. Dosage is based on your medical condition and response to therapy. Adults and children older than 15 should not take more than 15 milligrams daily. Children aged 12-15 should not take more than 7.5 milligrams daily. For children under 12, follow the doctor's directions for daily limits.Take this medication exactly as prescribed. Do not take more of this medication or take it more often than recommended by your doctor. If you have been directed to use this medication on a daily schedule, use it regularly at the same times each day in order to get the most benefit from it.If you take other asthma drugs by mouth or inhaling devices, ask your doctor about how to correctly take this medication with your other asthma medicines.If you notice less effect than usual from this medication, if your symptoms get worse, or if you feel you need to take any of your asthma medications more often than recommended, seek immediate medical attention.

              SIDE EFFECTS: Nervousness, shaking (tremor), dizziness, drowsiness or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.Tell your doctor right away if any of these unlikely but serious side effects occur: fast/pounding/irregular heartbeat, chest pain, muscle cramps, weakness.Tell your doctor right away if this rare but very serious side effect occurs: seizures.Rarely, this medication has caused severe (rarely fatal), sudden worsening of breathing problems/asthma (paradoxical bronchospasm). If you experience sudden wheezing, seek immediate medical attention.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. See Warning Section.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: Before taking terbutaline, tell your doctor or pharmacist if you are allergic to it; or to similar bronchodilators (e.g., albuterol, metaproterenol, salmeterol); or to sympathomimetic drugs (e.g., epinephrine, pseudoephedrine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., abnormal heartbeat, ischemic heart disease, high blood pressure), seizures, overactive thyroid (hyperthyroidism), diabetes, low blood potassium level (hypokalemia).This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).The elderly may be at greater risk for the effects on the heart while using this drug.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. See Warning Section.Terbutaline passes into breast milk. Consult your doctor before breast-feeding.

              DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: unusual dizziness, dry mouth, severe headache, seizures, very fast heartbeat, severe nausea.

              NOTES: Do not share this medication with others.Laboratory and/or medical tests may be performed regularly to monitor your progress or check for side effects. Consult your doctor for more details.Avoid allergens, irritants, smoking and other factors that make asthma worse.Learn to use a peak flow meter, use it daily, and promptly report worsening asthma (such as readings in the yellow/red range or increased use of quick-relief inhalers).Have your blood pressure and pulse checked regularly while taking this medication. It may be best to learn how to monitor your own blood pressure and pulse. Discuss this with your doctor.

              MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

              STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

              MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

              Information last revised September 2021. Copyright(c) 2021 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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              Formulary

              FormularyPatient Discounts

              Adding plans allows you to compare formulary status to other drugs in the same class.

              To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

              Adding plans allows you to:

              • View the formulary and any restrictions for each plan.
              • Manage and view all your plans together – even plans in different states.
              • Compare formulary status to other drugs in the same class.
              • Access your plan list on any device – mobile or desktop.

              The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
              4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
              QL Quantity Limits
              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
              ST Step Therapy
              Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
              OR Other Restrictions
              Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
              Additional Offers
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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.