Cranberry (Herb/Suppl)

Brand and Other Names:American cranberry, black cranberry, more...European cranberry, low cranberry, mossberry, Oxycoccus macrocarpus, trailing swamp cranberry, Vaccinium edule, Vaccinium erythrocarpum, vaccinium macrocarpon, Vaccinium occycoccus, Vaccinium vitis
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Suggested Dosing

UTI, Prevention

Juice

  • Cranberry juice cocktail (26% cranberry juice): 10-16 oz/day PO
  • Cranberry juice: 15 mL BID PO

Capsule

  • 400 mg BID PO

Urinary Deodorizer for Incontinent Patients

Cranberry juice cocktail

  • 3-6 oz/day PO
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Suggested Uses

UTI (prevention), urinary deodorizer for incontinent patients, type 2 diabetes, chronic fatigue syndrome, scurvy, pleurisy, as a diuretic, antiseptic, antipyretic, & cancer

Efficacy

Studies show significant reduction in the risk of recurrent UTI's in the elderly, hospitalized patients, and pregnant women

No reliable evidence shows effectiveness for treating UTI

Urinary odor: Preliminary research shows there may be a reduction in urinary odor in patients receiving oral cranberry

Diabetes: Clinical studies show NO improvement in fasting blood glucose, HbA1c, fructosamine, triglyceride, HDL cholesterol, or LDL cholesterol levels in patients with type 2 diabetes

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Interactions

Interaction Checker

and Cranberry

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (1)

                  • warfarin

                    cranberry increases effects of warfarin by unknown mechanism. Minor/Significance Unknown. Theoretical interaction, based on case reports. Cranberry may inhibit cytochrome P450 2C9.

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                  Adverse Effects

                  GI upset, diarrhea, kidney stones at high doses

                  Increased risk of cancer oxalate uroliths in predisposed patients

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                  Warnings

                  Contraindications

                  History of kidney stones

                  Cautions

                  Atrophic gastritis, hypochlorhydria

                  Potential interaction with warfarin & increased bleeding risk

                  Potential hypersensitivity

                  No evidence for efficacy in treatment

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                  Pregnancy & Lactation

                  Pregnancy Category: avoid use

                  Lactation: avoid use

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Metabolism: N/A

                  Excretion: N/A

                  Mechanism of Action

                  Proanthocyanidins, other compounds prevent bacterial adherence to urothelium

                  Does not significantly decrease urine pH

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.