Chasteberry (Herb/Suppl)

Brand and Other Names:agnolyt, agnus castus, more...chaste tree, hemp tree, monks pepper, vitex agnus castus
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Suggested Dosing

Crude herb extract

20-240 mg/d div BID-TID PO

Fluid extract

40 gtt/d PO

Dried fruit extract

1.6-3 mg PO BID

Tincture

35-45 gtt PO TID

Other Information

PMS: 4-20 mg/d

PMDD: 20-40 mg/d

No more than 1800 mg/d

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Suggested Uses

Acne, benign prostatic hyperplasia, fibrocystic breast disease, impotence, infertility (female), lactation, menopausal symptoms, menstrual irregularities, premenstrual syndrome, progesterone insufficiency

Efficacy

RCT (BMJ 2001;322:134-137) demonstrated benefit vs. placebo

Possibly effective for treating premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS).

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Interactions

Interaction Checker

and Chasteberry

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (23)

                  • aripiprazole

                    chasteberry decreases effects of aripiprazole by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • benperidol

                    chasteberry decreases effects of benperidol by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • chlorpromazine

                    chasteberry decreases effects of chlorpromazine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • clozapine

                    chasteberry decreases effects of clozapine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • droperidol

                    chasteberry decreases effects of droperidol by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • fluphenazine

                    chasteberry decreases effects of fluphenazine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • haloperidol

                    chasteberry decreases effects of haloperidol by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • iloperidone

                    chasteberry decreases effects of iloperidone by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • loxapine

                    chasteberry decreases effects of loxapine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • loxapine inhaled

                    chasteberry decreases effects of loxapine inhaled by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • olanzapine

                    chasteberry decreases effects of olanzapine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • paliperidone

                    chasteberry decreases effects of paliperidone by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • perphenazine

                    chasteberry decreases effects of perphenazine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • pimozide

                    chasteberry decreases effects of pimozide by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • prochlorperazine

                    chasteberry decreases effects of prochlorperazine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • promethazine

                    chasteberry decreases effects of promethazine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • quetiapine

                    chasteberry decreases effects of quetiapine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • risperidone

                    chasteberry decreases effects of risperidone by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • thioridazine

                    chasteberry decreases effects of thioridazine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • thiothixene

                    chasteberry decreases effects of thiothixene by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • trifluoperazine

                    chasteberry decreases effects of trifluoperazine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • ziprasidone

                    chasteberry decreases effects of ziprasidone by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

                  • zotepine

                    chasteberry decreases effects of zotepine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).

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                  Adverse Effects

                  Frequency Not Defined

                  Acne

                  Agitation

                  Allergic reactions

                  Alopecia

                  Dry mouth

                  GI upset

                  Headache

                  Intramenstrual bleeding

                  Itching

                  Menstrual flow changes

                  Nausea

                  Rash

                  Tachycardia

                  Tiredness

                  Urticaria

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                  Warnings

                  Contraindications

                  Breast cancer, endometriosis, hormone sensitive conditions, ovarian cancer, uterine cancer, uterine fibroids

                  Cautions

                  In vitro fertilization

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                  Pregnancy & Lactation

                  Pregnancy Category: unsafe

                  Lactation: unsafe

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Metabolism: N/A

                  Excretion: N/A

                  Mechanism of Action

                  Increase progesterone:estrogen ratio by decreasing FSH release

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.