Siberian Ginseng (Herb/Suppl)

Brand and Other Names:Acanthopanax Senticosus, Devil's Bush, more...Eleuthero, eleutherococcus, Eleutherococcus Senticosus, Shigoka, Thorny Pepperbrush, Touch Me Not, Untouchable, Wild Pepper
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Suggested Dosing

0.6-3 g dried root PO qDay

400 mg standardized extract PO qDay/TID

Therapy for 30-60 days, followed by 2-3 weeks off

Extract standardized to 0.3% eleutheroside E

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Suggested Uses

Adaptogen: adapt to internal/external stressors, fight fatigue, increase stamina

Reduce severity/duration of herpes simplex type II infections

Arterosclerosis, athletic/work performance enhancement, chronic fatigue syndrome, craniocerebral trauma, diabetes, fibromyalgia, hypertension/hypotension, immunostimulant, neuroses

Efficacy

Possibly effective for common cold and herpes simplex virus type 2

Possibly ineffective for athletic performance

Insufficient reliable evidence on chronic fatigue syndrome, cognitive performance, heart disease, influenza, ischemic stroke and quality of life

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Interactions

Interaction Checker

and Siberian Ginseng

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (69)

                • aceclofenac

                  aceclofenac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • acemetacin

                  acemetacin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • agrimony

                  agrimony and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • alfalfa

                  alfalfa and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • alteplase

                  alteplase and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • American ginseng

                  American ginseng and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • antithrombin alfa

                  antithrombin alfa and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • antithrombin III

                  antithrombin III and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • argatroban

                  argatroban and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • aspirin

                  aspirin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • aspirin rectal

                  aspirin rectal and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • bemiparin

                  bemiparin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • bivalirudin

                  bivalirudin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • celecoxib

                  celecoxib and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • cinnamon

                  cinnamon and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • cordyceps

                  cordyceps and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • dabigatran

                  dabigatran and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • dalteparin

                  dalteparin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • diclofenac

                  diclofenac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • diflunisal

                  diflunisal and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • dong quai

                  dong quai and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • enoxaparin

                  enoxaparin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • epoprostenol

                  epoprostenol and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • etodolac

                  etodolac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • fennel

                  fennel and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • fenoprofen

                  fenoprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • feverfew

                  feverfew and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • flurbiprofen

                  flurbiprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • fondaparinux

                  fondaparinux and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • forskolin

                  forskolin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • garlic

                  garlic and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • ginger

                  ginger and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • ginkgo biloba

                  ginkgo biloba and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • heparin

                  heparin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • horse chestnut seed

                  horse chestnut seed and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen

                  ibuprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen IV

                  ibuprofen IV and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • indomethacin

                  indomethacin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • ketoprofen

                  ketoprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • ketorolac

                  ketorolac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • ketorolac intranasal

                  ketorolac intranasal and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • lornoxicam

                  lornoxicam and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • meclofenamate

                  meclofenamate and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • mefenamic acid

                  mefenamic acid and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • meloxicam

                  meloxicam and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • mistletoe

                  Siberian ginseng increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nabumetone

                  nabumetone and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • naproxen

                  naproxen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • nettle

                  Siberian ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • oxaprozin

                  oxaprozin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • panax ginseng

                  panax ginseng and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • parecoxib

                  parecoxib and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • pau d'arco

                  pau d'arco and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • phenindione

                  phenindione and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • phytoestrogens

                  phytoestrogens and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • piroxicam

                  piroxicam and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • protamine

                  protamine and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • reishi

                  reishi and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • reteplase

                  reteplase and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • salicylates (non-asa)

                  salicylates (non-asa) and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • salsalate

                  salsalate and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • sulfasalazine

                  sulfasalazine and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • sulindac

                  sulindac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • tenecteplase

                  tenecteplase and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.

                • tolfenamic acid

                  tolfenamic acid and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • tolmetin

                  tolmetin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • vitamin K1 (phytonadione)

                  Siberian ginseng increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                Minor (36)

                • amobarbital

                  Siberian ginseng increases effects of amobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • anamu

                  anamu and Siberian ginseng both increase anticoagulation. Minor/Significance Unknown.

                • azelastine

                  Siberian ginseng increases effects of azelastine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • brompheniramine

                  Siberian ginseng increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • butabarbital

                  Siberian ginseng increases effects of butabarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • butalbital

                  Siberian ginseng increases effects of butalbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • carbinoxamine

                  Siberian ginseng increases effects of carbinoxamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • chloral hydrate

                  Siberian ginseng increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • chlorpheniramine

                  Siberian ginseng increases effects of chlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • cinnarizine

                  Siberian ginseng increases effects of cinnarizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • clemastine

                  Siberian ginseng increases effects of clemastine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • cyclizine

                  Siberian ginseng increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • cyproheptadine

                  Siberian ginseng increases effects of cyproheptadine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • danshen

                  danshen and Siberian ginseng both increase anticoagulation. Minor/Significance Unknown.

                • devil's claw

                  devil's claw and Siberian ginseng both increase anticoagulation. Minor/Significance Unknown.

                • dexchlorpheniramine

                  Siberian ginseng increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • dexmedetomidine

                  Siberian ginseng increases effects of dexmedetomidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • digoxin

                  Siberian ginseng increases levels of digoxin by unknown mechanism. Minor/Significance Unknown.

                • dimenhydrinate

                  Siberian ginseng increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • diphenhydramine

                  Siberian ginseng increases effects of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • doxylamine

                  Siberian ginseng increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • hydroxyzine

                  Siberian ginseng increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • insulin aspart

                  Siberian ginseng increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin detemir

                  Siberian ginseng increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin glargine

                  Siberian ginseng increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin glulisine

                  Siberian ginseng increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin lispro

                  Siberian ginseng increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin NPH

                  Siberian ginseng increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin regular human

                  Siberian ginseng increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown.

                • pentobarbital

                  Siberian ginseng increases effects of pentobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • phenobarbital

                  Siberian ginseng increases effects of phenobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • primidone

                  Siberian ginseng increases effects of primidone by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • promethazine

                  Siberian ginseng increases effects of promethazine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • secobarbital

                  Siberian ginseng increases effects of secobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • triclofos

                  Siberian ginseng increases effects of triclofos by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • triprolidine

                  Siberian ginseng increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

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                Adverse Effects

                Frequency Not Defined

                Anxiety

                Drowsiness

                Headache

                Hypertension

                Hypoglycemia

                Insomnia

                Irritability

                Mastalgia

                Muscle spasms

                Nerve inflammation

                Palpitations

                Pericardial pain

                Tachycardia

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                Warnings

                Contraindications

                Breast cancer, endometrial cancer, endometriosis, febrile conditions, hormone sensitive conditions, hypertension, ovarian cancer, uterine fibroids

                Cautions

                CAD, cardiovascular disorders, mania, MI, psychiatric disorders, rheumatic heart disease, schizophrenia

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                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Eleuthorosides A through M modulate pituitary-adrenocortical axis

                Antioxidant and immunostimulant activity

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.